通过可见光驱动的烯丙醇和胺的三氟甲基化反应生成含 CF3 的环氧化合物和氮杂环丙烷。

Generation of CF3-containing epoxides and aziridines by visible-light-driven trifluoromethylation of allylic alcohols and amines.

机构信息

Department of Chemistry and Applied Chemistry, Hanyang University, 55 Hanyangdaehakro, Sangnokgu, ansan, Kyeonggido 426-791, Republic of Korea.

出版信息

Chemistry. 2013 May 10;19(20):6209-12. doi: 10.1002/chem.201300564. Epub 2013 Mar 28.

DOI:10.1002/chem.201300564

PMID:23553927

Abstract

Radical reactions! Efficient methods for the generation of CF3-containing epoxides and aziridines have been developed (see scheme). A variety of allylic alcohols and allylic amines were transformed into the corresponding epoxides and aziridines by using [Ru(bpy)3]Cl2 (bpy = 2,2'-bipyridine), CF3 I, and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (or N,N,N',N'-tetramethylethylenediamine, TMEDA) under visible-light irradiation.

摘要

自由基反应！已经开发出了生成含 CF3 的环氧化合物和氮丙啶的有效方法（见方案）。使用 [Ru(bpy)3]Cl2（bpy = 2,2'-联吡啶）、CF3I 和 1,8-二氮杂二环[5.4.0]十一-7-烯（DBU）（或 N,N,N',N'-四甲基乙二胺，TMEDA），在可见光照射下，各种烯丙醇和烯丙胺转化为相应的环氧化合物和氮丙啶。