Jin Ke, Wang Shixia, Huang Zuhu, Lu Shan
Department of Infectious Diseases, ; Jiangsu Province Key Laboratory in Infectious Diseases, ; China-US Vaccine Research Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;
J Biomed Res. 2010 Nov;24(6):411-6. doi: 10.1016/S1674-8301(10)60055-3.
Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in Western countries in the last two decades. However, there is limited information on the status of C. difficile infection in Chinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem of over-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potential risk factors that may contribute to C. difficile infection in China. A literature review of available published studies, including those in Chinese language-based journals, was conducted. A review of the currently available literature suggested the presence of C. difficile infections in China, but also suggested that these infections were not particularly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliable epidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identification of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to prevent C. difficile infection and the vast negative impact of such infections in China and other developing countries.
艰难梭菌感染在过去二十年已成为西方国家主要的医院感染之一。然而，关于中国医疗机构中艰难梭菌感染状况的信息有限。鉴于中国庞大且不断增加的老年人口以及广为人知的广谱抗生素过度使用问题，了解可能导致中国艰难梭菌感染的流行病学及潜在风险因素至关重要。我们对包括中文期刊发表的研究在内的现有已发表研究进行了文献综述。对当前现有文献的回顾表明中国存在艰难梭菌感染，但也表明这些感染并非特别地方性流行。这一发现应促使开展设计更完善、规模大幅扩大的研究，以便就中国艰难梭菌感染的实际状况得出更可靠的基于流行病学的结论，包括识别任何相关风险因素。此类信息对于制定适当策略以预防艰难梭菌感染及其在中国和其他发展中国家造成的巨大负面影响最终具有重要价值。
