Li Donghua, Wu Jie
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
J Biomed Res. 2010 Nov;24(6):417-23. doi: 10.1016/S1674-8301(10)60056-5.
Osteoporosis is a condition characterized by low bone mineral density (BMD) and micro-architectural changes in the bone tissue. The risk of osteoporosis is partly determined by genetic factors. The role of C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene has been investigated in postmenopausal osteoporosis. However, the relationship between MTHFR polymorphism and BMD is still controversial. We carried out a meta-analysis of 5,833 subjects to evaluate the association of MTHFR and BMD in postmenopausal women. Databases of MEDLINE, Web of Science, Scopus and CNKI were retrieved for all publications relating to MTHFR polymorphism and BMD in postmenopausal women. Five eligible studies were selected for meta-analysis. All these articles studied the association of MTHFR polymorphism and BMD of the femoral neck and lumbar spine in postmenopausal women. Our analysis suggested that postmenopausal women with the TT genotype had lower femoral neck BMD than the women with the CC/CT genotype, and the weighted mean difference (WMD) was -0.01 g/cm(2) [95% confidence interval (CI): (-0.01, -0.01), P < 0.01]. However, BMD of the lumbar spine of postmenopausal women with the TT genotype was not significantly different from that of women with the CC/CT genotype. In the random effects model, the WMD between the TT and TC/CC genotype was -0.01 g/cm(2) [95% CI: (-0.04, 0.01), P = 0.32]. The C677T polymorphism of the MTHFR gene is associated with BMD of the femoral neck in postmenopausal women. Women with the TT genotype of the MTHFR gene have lower BMD, suggesting that the TT genotype may be a risk factor for postmenopausal osteoporosis.
骨质疏松症是一种以骨矿物质密度（BMD）降低和骨组织微观结构改变为特征的病症。骨质疏松症的风险部分由遗传因素决定。亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性在绝经后骨质疏松症中的作用已得到研究。然而，MTHFR多态性与BMD之间的关系仍存在争议。我们对5833名受试者进行了一项荟萃分析，以评估MTHFR与绝经后女性BMD之间的关联。检索了MEDLINE、科学网、Scopus和中国知网数据库中所有与绝经后女性MTHFR多态性和BMD相关的出版物。选择了五项符合条件的研究进行荟萃分析。所有这些文章都研究了绝经后女性MTHFR多态性与股骨颈和腰椎BMD之间的关联。我们的分析表明，TT基因型的绝经后女性股骨颈BMD低于CC/CT基因型的女性，加权平均差（WMD）为-0.01 g/cm² [95%置信区间（CI）：（-0.01，-0.01），P < 0.01]。然而，TT基因型的绝经后女性腰椎BMD与CC/CT基因型的女性相比无显著差异。在随机效应模型中，TT与TC/CC基因型之间的WMD为-0.01 g/cm² [95% CI：（-0.04，0.01），P = 0.32]。MTHFR基因的C677T多态性与绝经后女性股骨颈BMD相关。MTHFR基因TT基因型的女性BMD较低，表明TT基因型可能是绝经后骨质疏松症的一个危险因素。
