Udayakumar Mani, Shanmuga-Priya Palaniyandi, Hemavathi Kamalakannan, Seenivasagam Rengasamy
Department of Bioinformatics;
J Biomed Res. 2011 Nov;25(6):444-8. doi: 10.1016/S1674-8301(11)60059-6.
Active Motif Finder (AMF) is a novel algorithmic tool, designed based on mutations in DNA sequences. Tools available at present for finding motifs are based on matching a given motif in the query sequence. AMF describes a new algorithm that identifies the occurrences of patterns which possess all kinds of mutations like insertion, deletion and mismatch. The algorithm is mainly based on the Alignment Score Matrix (ASM) computation by comparing input motif with full length sequence. Much of the effort in bioinformatics is directed to identify these motifs in the sequences of newly discovered genes. The proposed bio-tool serves as an open resource for analysis and useful for studying polymorphisms in DNA sequences. AMF can be searched via a user-friendly interface. This tool is intended to serve the scientific community working in the areas of chemical and structural biology, and is freely available to all users, at http://www.sastra.edu/scbt/amf/.
活性基序查找器（AMF）是一种新颖的算法工具，它基于DNA序列中的突变进行设计。目前可用于查找基序的工具是基于在查询序列中匹配给定基序。AMF描述了一种新算法，该算法可识别具有插入、缺失和错配等各种突变的模式的出现情况。该算法主要基于通过将输入基序与全长序列进行比较来计算比对得分矩阵（ASM）。生物信息学中的许多工作都致力于在新发现基因的序列中识别这些基序。所提出的生物工具可作为一种开放资源用于分析，并且对于研究DNA序列中的多态性很有用。可以通过用户友好的界面搜索AMF。该工具旨在为从事化学和结构生物学领域工作的科学界服务，并且所有用户都可以在http://www.sastra.edu/scbt/amf/上免费使用。
