Cai Jing, Sheng Yanhui, Zhang Shijiang, Sun Wei, Yang Rong, Miao Liping, Kong Xiangqing
Department of Cardiology.
J Biomed Res. 2012 May;26(3):211-8. doi: 10.7555/JBR.26.20120011. Epub 2012 May 17.
We sought to evaluate the feasibility and hemodynamic performance of a new self-expanding bioprosthesis and 16-F delivery system in sheep. A 23-mm new self-expanding aortic bioprosthesis was implanted in sheep (n = 10) with a 16-F catheter via the right common carotid artery. Each sheep underwent angiography and coronary angiography before intervention, immediately and 1 h after stent implantation. Electrocardiographic monitoring was carried out during and 2 h after the procedure. Transthoracic echocardiography was employed to detect hemodynamic performance before intervention, immediately and 1 and 2 h after stent implantation. All sheep were euthanized 2 h after successful implantation for macroscopic inspection. In all cases, the new self-expanding aortic bioprosthesis was successfully delivered to the aortic root and released with a 16-F catheter. Successful implantation was achieved in 8 of 10 sheep. Hemodynamic performance and device position of successful implantation were stable 2 h after device deployment. Atrioventricular block was not observed. We conclude that it is feasible to implant the new self-expanding aortic valve with a 16-F delivery system into sheep hearts via the retrograde route.
我们试图评估一种新型自膨胀生物假体及16F输送系统在绵羊体内的可行性和血流动力学性能。通过右颈总动脉，使用16F导管将一个23mm的新型自膨胀主动脉生物假体植入10只绵羊体内。每只绵羊在干预前、支架植入后即刻及1小时后接受血管造影和冠状动脉造影。在手术过程中及术后2小时进行心电图监测。采用经胸超声心动图检测干预前、支架植入后即刻及1小时和2小时后的血流动力学性能。成功植入后2小时，所有绵羊均实施安乐死以进行宏观检查。在所有病例中，新型自膨胀主动脉生物假体均通过16F导管成功输送至主动脉根部并释放。10只绵羊中有8只成功植入。装置部署后2小时，成功植入的血流动力学性能和装置位置稳定。未观察到房室传导阻滞。我们得出结论，通过逆行途径使用16F输送系统将新型自膨胀主动脉瓣膜植入绵羊心脏是可行的。
