应用全血细胞计数开发一种预后评分，用于预测未经选择的危重症患者的生存情况。
Development of a prognostic score using the complete blood cell count for survival prediction in unselected critically ill patients.
机构信息
Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.
出版信息
Biomed Res Int. 2013;2013:105319. doi: 10.1155/2013/105319. Epub 2013 Feb 28.
OBJECTIVE
The purpose of this study was to develop a new prognostic scoring system for critically ill patients using the simple complete blood cell count (CBC).
METHODS
CBC measurements in samples from 306 patients in an intensive care unit were conducted with automated analyzers, including levels of neutrophils, lymphocytes, erythrocytes, hemoglobin, and platelets. The time of sampling and the time of death were recorded. Z values were calculated according to the measured values, reference mean values, and standard deviations. The prognostic score was equivalent to the median of the Z value of each of the measured parameters.
RESULTS
There was a significant correlation between survival time and neutrophil, lymphocyte, and platelet levels (P < 0.05). Prognostic scores were calculated from the Z value of these three parameters. Survival times decreased as the prognostic score increased.
CONCLUSIONS
This study suggests that a model that uses levels of neutrophils, lymphocytes, and platelets is potentially useful in the objective evaluation of survival time or disease severity in unselected critically ill patients.
目的
本研究旨在使用简单的全血细胞计数（CBC）为危重症患者开发新的预后评分系统。
方法
使用自动分析仪对重症监护病房 306 名患者的样本进行 CBC 测量，包括中性粒细胞、淋巴细胞、红细胞、血红蛋白和血小板水平。记录采样时间和死亡时间。根据测量值、参考平均值和标准差计算 Z 值。预后评分等于每个测量参数的 Z 值的中位数。
结果
存活时间与中性粒细胞、淋巴细胞和血小板水平呈显著相关（P<0.05）。从这三个参数的 Z 值计算预后评分。随着预后评分的增加，存活时间减少。
结论
本研究表明，使用中性粒细胞、淋巴细胞和血小板水平的模型可能有助于客观评估未经选择的危重症患者的存活时间或疾病严重程度。
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