Department of Radiation Oncology, Seoul National University Hospital, Seoul110-744, South Korea.
Med Phys. 2013 Apr;40(4):041721. doi: 10.1118/1.4797469.
To develop a fast and robust technique for the determination of optimized photon spectra for flattening filter free (FFF) beams to be applied in convolution/superposition dose calculations.
A two-step optimization method was developed to derive optimal photon spectra for FFF beams. In the first step, a simple functional form of the photon spectra proposed by Ali ["Functional forms for photon spectra of clinical linacs," Phys. Med. Biol. 57, 31-50 (2011)] is used to determine generalized shapes of the photon spectra. In this method, the photon spectra were defined for the ranges of field sizes to consider the variations of the contributions of scattered photons with field size. Percent depth doses (PDDs) for each field size were measured and calculated to define a cost function, and a collapsed cone convolution (CCC) algorithm was used to calculate the PDDs. In the second step, the generalized functional form of the photon spectra was fine-tuned in a process whereby the weights of photon fluence became the optimizing free parameters. A line search method was used for the optimization and first order derivatives with respect to the optimizing parameters were derived from the CCC algorithm to enhance the speed of the optimization. The derived photon spectra were evaluated, and the dose distributions using the optimized spectra were validated.
The optimal spectra demonstrate small variations with field size for the 6 MV FFF beam and relatively large variations for the 10 MV FFF beam. The mean energies of the optimized 6 MV FFF spectra were decreased from 1.31 MeV for a 3 × 3 cm(2) field to 1.21 MeV for a 40 × 40 cm(2) field, and from 2.33 MeV at 3 × 3 cm(2) to 2.18 MeV at 40 × 40 cm(2) for the 10 MV FFF beam. The developed method could significantly improve the agreement between the calculated and measured PDDs. Root mean square differences on the optimized PDDs were observed to be 0.41% (3 × 3 cm(2)) down to 0.21% (40 × 40 cm(2)) for the 6 MV FFF beam, and 0.35% (3 × 3 cm(2)) down to 0.29% (40 × 40 cm(2)) for the 10 MV FFF beam. The first order derivatives from the functional form were found to improve the speed of computational time up to 20 times compared to the other techniques.
The derived photon spectra resulted in good agreements with measured PDDs over the range of field sizes investigated. The suggested method is easily applicable to commercial radiation treatment planning systems since it only requires measured PDDs as input.
开发一种快速而稳健的技术,以确定适用于卷积/叠加剂量计算的适形调强(FFF)射束的优化光子能谱。
开发了一种两步优化方法来推导 FFF 射束的最佳光子能谱。在第一步中,使用 Ali 提出的光子能谱简单函数形式["临床直线加速器的光子能谱函数形式",Phys. Med. Biol. 57, 31-50 (2011)]来确定光子能谱的广义形状。在该方法中,定义了用于考虑散射光子随射野大小变化的贡献的射野大小范围的光子能谱。测量并计算每个射野大小的百分深度剂量(PDD)来定义成本函数,并使用折叠锥卷积(CCC)算法计算 PDD。在第二步中,通过微调光子通量权重作为优化自由参数的过程来微调广义光子能谱函数形式。使用线搜索方法进行优化,并从 CCC 算法中导出相对于优化参数的一阶导数,以提高优化速度。评估推导的光子能谱,并验证使用优化能谱的剂量分布。
对于 6 MV FFF 射束,优化后的光谱随射野大小的变化较小,而对于 10 MV FFF 射束,变化较大。优化后的 6 MV FFF 光谱的平均能量从 3×3 cm(2)的 1.31 MeV 降低到 40×40 cm(2)的 1.21 MeV,而 10 MV FFF 射束从 3×3 cm(2)的 2.33 MeV 降低到 40×40 cm(2)的 2.18 MeV。所开发的方法可以显著改善计算和测量的 PDD 之间的一致性。对于 6 MV FFF 射束,优化后的 PDD 的均方根差异从 3×3 cm(2)的 0.41%降低到 40×40 cm(2)的 0.21%,从 3×3 cm(2)的 0.35%降低到 40×40 cm(2)的 0.29%。对于 10 MV FFF 射束,从功能形式得出的一阶导数被发现可以将计算时间提高 20 倍,与其他技术相比。
在所研究的射野范围内,推导的光子能谱与测量的 PDD 之间产生了良好的一致性。所提出的方法很容易适用于商业放射治疗计划系统,因为它只需要测量的 PDD 作为输入。