人巨细胞病毒是否与乳腺癌的进展有关？
Is human cytomegalovirus associated with breast cancer progression?
机构信息
Medical Research Unit in Human Genetics, Pediatrics Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, 06720, Mexico.
出版信息
Infect Agent Cancer. 2013 Apr 4;8(1):12. doi: 10.1186/1750-9378-8-12.
BACKGROUND
It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possible association with breast cancer progression. DNA from paraffin-embedded tissues was analyzed by real-time PCR. We investigated 20 fibroadenomas and 27 primary breast carcinomas (stages II, III, and IV).
FINDINGS
Two carcinomas were positive for HCMV, one was positive for two TaqMan viral detection probes, and one was positive for a sole TaqMan viral detection probe (UL83), whereas the remainder of the samples was negative.
CONCLUSIONS
Samples studied showed no association between HCMV infection and breast cancer progression.
背景
有假说认为人类巨细胞病毒（HCMV）可能与乳腺癌的进展有关。然而，HCMV 感染在乳腺癌中的作用仍存在争议。本研究旨在评估 HCMV 基因（UL122 和 UL83）能否在乳腺癌中被检测到，并重新研究其与乳腺癌进展的可能关联。采用实时 PCR 法分析石蜡包埋组织中的 DNA。我们研究了 20 例纤维腺瘤和 27 例原发性乳腺癌（II、III 和 IV 期）。
结果
有两个癌组织呈 HCMV 阳性，一个癌组织对两个 TaqMan 病毒检测探针呈阳性，一个癌组织仅对 TaqMan 病毒检测探针（UL83）呈阳性，而其余样本均为阴性。
结论
本研究样本未显示 HCMV 感染与乳腺癌进展之间存在关联。
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