巨细胞病毒与结直肠癌的进展和转移无关。

Cytomegalovirus is not associated with progression and metastasis of colorectal cancer.

作者信息

Knösel Thomas, Schewe Christiane, Dietel Manfred, Petersen Iver

机构信息

Institute of Pathology, University Hospital, Charité-Campus Mitte, Schumannstrasse 20/21, D-10098 Berlin, Germany.

出版信息

Cancer Lett. 2004 Aug 10;211(2):243-7. doi: 10.1016/j.canlet.2004.02.011.

DOI:10.1016/j.canlet.2004.02.011

PMID:15219948

Abstract

Recently, it was hypothesized that human cytomegalovirus (HCMV) might be associated with colorectal cancer progression. However, the role of HCMV infection in colorectal cancer remains controversial. We aimed to assess whether nucleic acids and/or gene products of HCMV could be detected in primary and metastatic colorectal carcinomas. Fresh-frozen biopsy specimens from 77 primary and metastatic colorectal carcinomas of randomly selected patients were analyzed by PCR and immunohistochemistry. We investigated 57 primary tumors and 20 metastases, comprising 13 tumor pairs from the same patient. In PCR, four primary tumors showed a positive CMV result whereas all investigated metastases were negative including three paired samples from positive primaries. In immunohistochemistry, no specific staining could be determined in all neoplastic epithelial cells. In summary, we think that there is no association between CMV infection and tumor progression or metastasis formation of colorectal cancer.

摘要

最近，有人提出假设，即人类巨细胞病毒（HCMV）可能与结直肠癌进展有关。然而，HCMV感染在结直肠癌中的作用仍存在争议。我们旨在评估在原发性和转移性结直肠癌中是否能检测到HCMV的核酸和/或基因产物。通过聚合酶链反应（PCR）和免疫组织化学对随机选择的患者的77例原发性和转移性结直肠癌的新鲜冷冻活检标本进行了分析。我们研究了57例原发性肿瘤和20例转移灶，其中包括来自同一患者的13对肿瘤。在PCR检测中，4例原发性肿瘤显示CMV结果为阳性，而所有研究的转移灶均为阴性，包括来自阳性原发性肿瘤的3对配对样本。在免疫组织化学检测中，所有肿瘤上皮细胞均未发现特异性染色。总之，我们认为CMV感染与结直肠癌的肿瘤进展或转移形成之间没有关联。