Division of Dermatology and Cutaneous Surgery, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Dermatol Clin. 2013 Apr;31(2):229-37. doi: 10.1016/j.det.2012.12.002. Epub 2013 Feb 1.
This article outlines the epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment of childhood morphea. Also known as localized scleroderma, morphea is a fibrosing disorder of the skin and subcutaneous tissues. Morphea is differentiated from systemic sclerosis (scleroderma) based on the absence of sclerodactyly, Raynaud phenomenon, and nail-fold capillary changes. Confusion may occur because patients with morphea often have systemic symptoms such as malaise, fatigue, arthralgias, myalgias, and positive autoantibodies. Unlike morphea, systemic sclerosis has organ involvement, particularly gastrointestinal, pulmonary, and renal.
本文概述了儿童硬斑病的流行病学、发病机制、临床表现、诊断和治疗。硬斑病又称局限性硬皮病，是一种皮肤和皮下组织的纤维性疾病。硬斑病与系统性硬化症（硬皮病）的区别在于无硬皮病、雷诺现象和甲襞毛细血管变化。由于硬斑病患者常有全身症状，如不适、疲劳、关节痛、肌痛和自身抗体阳性，因此可能会出现混淆。与硬斑病不同，系统性硬化症有器官受累，特别是胃肠道、肺部和肾脏。
