Stark G B, Dorer A, Walgenbach K J, Grünwald F, Jaeger K
Division of Plastic Surgery, Tulane University Medical Center, New Orleans.
Langenbecks Arch Chir. 1990;375(3):145-50. doi: 10.1007/BF00206807.
Tissue expanders (inflatable silicone balloons) were implanted into a bypassed ileum segment of seven pigs and consecutively filled over 8 to 12 weeks. The mean increase of the volume of the small bowel loops was 12 fold with a maximum of 22.8 times the original volume. The final volume 9 weeks after expander removal still presented an increase of 500%. Histologically there was an increase of the thickness of all layers of the bowel wall, especially in the tunica muscularis. The mucosa showed a value above normal in mean in vitro 14C-resorption capacity per surface area in the reintegrated bowel. Possible clinical applications of the augmentation of the gut by expansion as a rectum substitute after proctocolectomy, as a urinary bladder or stomach substitute, and for the treatment of short bowel syndrome are discussed.
将组织扩张器（可充气硅胶球囊）植入7头猪的一段旷置回肠中，并在8至12周内连续充盈。小肠袢体积平均增加了12倍，最大达到原始体积的22.8倍。取出扩张器9周后的最终体积仍增加了500%。组织学检查显示肠壁各层厚度增加，尤其是肌层。在重新整合的肠段中，黏膜每表面积的平均体外14C吸收能力高于正常水平。讨论了通过扩张增加肠道容量作为直肠切除术后直肠替代物、膀胱或胃替代物以及治疗短肠综合征的可能临床应用。
