Ege University, School of Dentistry, Department of Oral Maxillofacial Radiology, Izmir, Turkey.
Clin Exp Rheumatol. 2013 May-Jun;31(3 Suppl 77):15-9. Epub 2013 Apr 2.
The aim of this study was to investigate oral and general health-related quality of life (QoL) in patients with familial Mediterranean fever (FMF) disease.
In this cross-sectional study, 45 patients with FMF, 50 age- and sex-matched healthy controls (HC), and 50 patients with Behçet's disease (BD) as the disease control group were included. FMF disease activity was evaluated by using the FMF-severity score, as well as with erythrocyte sedimentation rate (ESR), and serum C-reactive protein and fibrinogen levels. Oral health-related QoL and general QoL were evaluated using oral health impact profile-14 (OHIP-14) and Medical Outcomes Short-Form Health Survey Questionnaire 36 (SF-36), respectively.
Only the numbers of extracted teeth (4.13±4.72 vs. 1.55±3.6) and filled teeth (2.33±3.19 vs. 0.66±1.46) were significantly higher in FMF group compared to HC group (p=0.005 and p=0.013, respectively). OHIP-14 score was significantly higher in FMF and BD groups compared to HC group. In FMF patients, OHIP-14 score was positively correlated with the number of extracted teeth (r=0.38, p=0.010), while the number of carious teeth was positively correlated with ESR (r=0.43, p=0.003). When FMF patients were sub-classified according to disease severity, no significant difference was observed with respect to oral health status.
In patients with FMF, some of the parameters of oral health status were found to be worse compared to HC group. Tooth loss appears to be to be a critical factor contributing to impaired oral QoL. In general, oral health status in FMF patients is better than in BD patients.
本研究旨在探讨家族性地中海热（FMF）患者的口腔健康相关生活质量（QoL）和一般健康相关 QoL。
在这项横断面研究中，纳入了 45 名 FMF 患者、50 名年龄和性别匹配的健康对照者（HC）和 50 名作为疾病对照组的贝切特病（BD）患者。通过 FMF 严重程度评分以及红细胞沉降率（ESR）和血清 C 反应蛋白和纤维蛋白原水平来评估 FMF 疾病活动度。使用口腔健康影响简表 14 项（OHIP-14）和医疗结局研究 36 项简短健康调查问卷（SF-36）分别评估口腔健康相关 QoL 和一般 QoL。
与 HC 组相比，FMF 组的拔牙数（4.13±4.72 比 1.55±3.6）和补牙数（2.33±3.19 比 0.66±1.46）显著更高（p=0.005 和 p=0.013）。FMF 和 BD 组的 OHIP-14 评分均显著高于 HC 组。在 FMF 患者中，OHIP-14 评分与拔牙数呈正相关（r=0.38，p=0.010），而龋齿数与 ESR 呈正相关（r=0.43，p=0.003）。根据疾病严重程度对 FMF 患者进行分类时，口腔健康状况无显著差异。
与 HC 组相比，FMF 患者的一些口腔健康状况参数较差。牙齿缺失似乎是导致口腔 QoL 受损的一个关键因素。总体而言，FMF 患者的口腔健康状况优于 BD 患者。
