Anholeti Maria C, Duprat Rodrigo C, Figueiredo Maria R, Kaplan Maria Ac, Santos Marcelo Guerra, Gonzalez Marcelo S, Ratcliffe Norman A, Feder Denise, Paiva Selma R, Mello Cicero B
Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, BR.
Laboratório de Biologia de Insetos, Universidade Federal Fluminense, Niterói, RJ, BR.
Mem Inst Oswaldo Cruz. 2015 Aug;110(5):629-35. doi: 10.1590/0074-02760150103. Epub 2015 Jul 17.
Studies evaluated the effects of hexanic extracts from the fruits and flowers of Clusia fluminensis and the main component of the flower extract, a purified benzophenone (clusianone), against Aedes aegypti. The treatment of larvae with the crude fruit or flower extracts from C. fluminensis did not affect the survival ofAe. aegypti (50 mg/L), however, the flower extracts significantly delayed development of Ae. aegypti. In contrast, the clusianone (50 mg/L) isolate from the flower extract, representing 54.85% of this sample composition, showed a highly significant inhibition of survival, killing 93.3% of the larvae and completely blocking development of Ae. aegypti. The results showed, for the first time, high activity of clusianone against Ae. aegypti that both killed and inhibited mosquito development. Therefore, clusianone has potential for development as a biopesticide for controlling insect vectors of tropical diseases. Future work will elucidate the mode of action of clusianone isolated from C. fluminensis.
研究评估了巴西克鲁西亚木果实和花朵的己烷提取物以及花朵提取物的主要成分——一种纯化的二苯甲酮（克鲁西酮）对埃及伊蚊的影响。用巴西克鲁西亚木的粗制果实或花朵提取物处理幼虫，对埃及伊蚊（50毫克/升）的存活率没有影响，然而，花朵提取物显著延迟了埃及伊蚊的发育。相比之下，从花朵提取物中分离出的克鲁西酮（50毫克/升）占该样品成分的54.85%，显示出对存活率的高度显著抑制，杀死了93.3%的幼虫，并完全阻断了埃及伊蚊的发育。结果首次表明，克鲁西酮对埃及伊蚊具有高活性，既能杀死蚊子又能抑制其发育。因此，克鲁西酮有潜力开发成为一种用于控制热带疾病昆虫媒介的生物杀虫剂。未来的工作将阐明从巴西克鲁西亚木中分离出的克鲁西酮的作用模式。
