鼻咽癌放疗后并发放射性甲状腺功能减退症患者甲状腺抗体与甲状腺激素水平的纵向研究。
Longitudinal study on the correlations of thyroid antibody and thyroid hormone levels after radiotherapy in patients with nasopharyngeal carcinoma with radiation-induced hypothyroidism.
机构信息
Cancer Hospital, Shantou University Medical College, Shantou, Guangdong, China.
出版信息
Head Neck. 2014 Feb;36(2):171-5. doi: 10.1002/hed.23285. Epub 2013 Apr 4.
BACKGROUND
The purpose of this study was to evaluate the correlations of thyroid antibody and thyroid hormone in postradiotherapy (post-RT) patients with nasopharyngeal carcinoma (NPC).
METHODS
Serum thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroperoxidase antibody (anti-TPO), and thyroglobulin antibody (anti-TG) levels of 55 patients with NPC were taken before RT and at 3, 6, 12, and 18 months after RT. Patients with hypothyroidism at 18 months after RT and those with normal thyroid function were categorized into the hypo and normal groups, respectively. The thyroid antibody levels were compared between the 2 groups, and the correlations of thyroid antibody and thyroid hormone were evaluated for the hypo group.
RESULTS
The anti-TPO and anti-TG of the hypo group were higher than the normal group. In the hypo group, there was a positive correlation (r = 0.51) between TSH and anti-TG and a negative correlation between fT4 and anti-TPO (r = -0.55).
CONCLUSION
There were correlations of the thyroid antibody and thyroid hormone levels in patients with radiation-induced hypothyroidism.
背景
本研究旨在评估鼻咽癌（NPC）放疗后患者甲状腺抗体和甲状腺激素之间的相关性。
方法
检测 55 例 NPC 患者放疗前和放疗后 3、6、12、18 个月的血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（fT3）、游离甲状腺素（fT4）、甲状腺过氧化物酶抗体（anti-TPO）和甲状腺球蛋白抗体（anti-TG）水平。将放疗后 18 个月出现甲状腺功能减退的患者和甲状腺功能正常的患者分别分为甲减组和正常组。比较两组的甲状腺抗体水平，并对甲减组进行甲状腺抗体与甲状腺激素的相关性分析。
结果
甲减组的 anti-TPO 和 anti-TG 高于正常组。在甲减组中，TSH 与 anti-TG 呈正相关（r = 0.51），fT4 与 anti-TPO 呈负相关（r = -0.55）。
结论
放射性甲状腺功能减退患者的甲状腺抗体和甲状腺激素水平存在相关性。
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