Hamid Rifat, Khan Minhaj A, Ahmad Mahboob, Ahmad Malik Mobeen, Abdin Malik Zainul, Musarrat Javed, Javed Saleem
Department of Biochemistry, Faculty of Science, Jamia Hamdard, New Delhi, India.
J Pharm Bioallied Sci. 2013 Jan;5(1):21-9. doi: 10.4103/0975-7406.106559.
Chitin, the second most abundant polysaccharide in nature after cellulose, is found in the exoskeleton of insects, fungi, yeast, and algae, and in the internal structures of other vertebrates. Chitinases are enzymes that degrade chitin. Chitinases contribute to the generation of carbon and nitrogen in the ecosystem. Chitin and chitinolytic enzymes are gaining importance for their biotechnological applications, especially the chitinases exploited in agriculture fields to control pathogens. Chitinases have a use in human health care, especially in human diseases like asthma. Chitinases have wide-ranging applications including the preparation of pharmaceutically important chitooligosaccharides and N-acetyl D glucosamine, preparation of single-cell protein, isolation of protoplasts from fungi and yeast, control of pathogenic fungi, treatment of chitinous waste, mosquito control and morphogenesis, etc. In this review, the various types of chitinases and the chitinases found in different organisms such as bacteria, plants, fungi, and mammals are discussed.
几丁质是自然界中仅次于纤维素的第二丰富的多糖,存在于昆虫、真菌、酵母和藻类的外骨骼以及其他脊椎动物的内部结构中。几丁质酶是降解几丁质的酶。几丁质酶有助于生态系统中碳和氮的生成。几丁质和几丁质分解酶因其生物技术应用而变得越来越重要,特别是在农业领域用于控制病原体的几丁质酶。几丁质酶在人类医疗保健中有用途,尤其是在哮喘等人类疾病中。几丁质酶有广泛的应用,包括制备具有重要药学意义的壳寡糖和N-乙酰-D-葡萄糖胺、制备单细胞蛋白、从真菌和酵母中分离原生质体、控制致病真菌、处理含几丁质的废物、控制蚊子和形态发生等。在这篇综述中,讨论了不同类型的几丁质酶以及在细菌、植物、真菌和哺乳动物等不同生物体中发现的几丁质酶。