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2
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3
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Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes.过氧化物酶体增殖物激活受体γ基因Pro12Ala多态性的丙氨酸变体可能与2型糖尿病患者糖尿病视网膜病变风险降低有关。
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Polymorphisms of the peroxisome proliferator-activated receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus.过氧化物酶体增殖物激活受体γ（rs1801282）及其辅激活因子-1（rs8192673）的多态性与2型糖尿病患者的肥胖指标相关。
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Front Endocrinol (Lausanne). 2022 Jun 6;13:915031. doi: 10.3389/fendo.2022.915031. eCollection 2022.
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PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis.PPARG（Pro12Ala）基因变异与 T2DM 风险：系统评价和荟萃分析。
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Association of Peroxisome Proliferator-Activated Receptors (PPARs) with Diabetic Retinopathy in Human and Animal Models: Analysis of the Literature and Genome Browsers.过氧化物酶体增殖物激活受体（PPARs）与人类和动物模型糖尿病视网膜病变的关联：文献及基因组浏览器分析
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Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus.过氧化物酶体增殖物激活受体γ基因多态性（rs1801282）与埃及冠心病合并2型糖尿病患者的肥胖相关。
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本文引用的文献

1
Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study).新型水溶性姜黄素衍生物对实验性 1 型糖尿病（短期研究）的影响。
Diabetol Metab Syndr. 2012 Jul 4;4(1):30. doi: 10.1186/1758-5996-4-30.
2
Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies.过氧化物酶体增殖物激活受体 γ 多态性 Pro12Ala 与 2 型糖尿病肾病有关：来自 18 项研究的荟萃分析证据。
Diabetes Care. 2012 Jun;35(6):1388-93. doi: 10.2337/dc11-2142.
3
Risk factors associated with diabetic retinopathy in patients with diabetes mellitus type 2.2型糖尿病患者糖尿病视网膜病变的相关危险因素。
BMC Res Notes. 2010 Jun 1;3:153. doi: 10.1186/1756-0500-3-153.
4
Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy.意大利与2型糖尿病及糖尿病视网膜病变相关的PPARG调控区域新型多态性的特征分析
J Biomed Biotechnol. 2009;2009:126917. doi: 10.1155/2009/126917. Epub 2008 Dec 25.
5
Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response.对糖尿病视网膜反应的全基因组评估揭示了一种渐进性神经血管炎症反应。
BMC Med Genomics. 2008 Jun 13;1:26. doi: 10.1186/1755-8794-1-26.
6
Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes.过氧化物酶体增殖物激活受体γ基因Pro12Ala多态性的丙氨酸变体可能与2型糖尿病患者糖尿病视网膜病变风险降低有关。
Diabetes Res Clin Pract. 2008 Apr;80(1):139-45. doi: 10.1016/j.diabres.2007.11.001. Epub 2008 Feb 20.
7
An analysis of peroxisome proliferator-activated receptor gamma (PPAR-gamma 2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits.过氧化物酶体增殖物激活受体γ（PPAR-γ2）Pro12Ala多态性分布及饮食习惯与世界人群2型糖尿病（T2DM）患病率的分析
Nutr Metab Cardiovasc Dis. 2007 Nov;17(9):632-41. doi: 10.1016/j.numecd.2006.12.007. Epub 2007 Apr 16.
8
Effects of peroxisome proliferator-activated receptor gamma and its ligand on blood-retinal barrier in a streptozotocin-induced diabetic model.过氧化物酶体增殖物激活受体γ及其配体对链脲佐菌素诱导的糖尿病模型血视网膜屏障的影响
Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4547-52. doi: 10.1167/iovs.05-1432.
9
Lack of association between the Pro12Ala polymorphism in PPAR-gamma2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes.PPAR-γ2基因Pro12Ala多态性与2型糖尿病肥胖患者体重变化、胰岛素抵抗及慢性糖尿病并发症之间无关联。
Arch Med Res. 2006 Aug;37(6):736-43. doi: 10.1016/j.arcmed.2006.01.009.
10
Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity.过氧化物酶体增殖物激活受体γ2 Pro12Ala基因多态性在南亚和白种人糖尿病种族易感性中的作用：异质性证据
Diabetes Care. 2006 May;29(5):1046-51. doi: 10.2337/diacare.2951046.

过氧化物酶体增殖物激活受体γ基因Pro12Ala多态性与增殖性糖尿病视网膜病变的相关性

Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy.

作者信息

Tariq Khadija, Malik Saira Bano, Ali Syeda Hafiza Benish, Maqsood Sundas Ejaz, Azam Aisha, Muslim Irfan, Khan Muhammad Shakil, Azam Maleeha, Waheed Nadia Khalida, Qamar Raheel

机构信息

Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan.

出版信息

Mol Vis. 2013;19:710-7. Epub 2013 Mar 21.

PMID:23559865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3611930/
Abstract

PURPOSE

The association of non-synonymous substitution polymorphism rs1801282 (c.34C>G, p.Pro12Ala) in exon 4 of the peroxisome proliferator activated receptor gamma gene with diabetic retinopathy (DR) has been reported inconsistently. Therefore, the purpose of the present study was to understand the population-specific role of the Pro12Ala polymorphism in DR susceptibility in Pakistani subjects.

METHODS

A total of 180 subjects with DR, 193 subjects with type 2 diabetes mellitus (T2DM) with no diabetic retinopathy, and 200 healthy normoglycemic non-retinopathic Pakistani individuals were genotyped for the rs1801282 (c.34C>G) polymorphism using polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

We found the individuals with T2DM carrying 12Ala were at a reduced risk of developing DR (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.33-0.87). Upon stratified analysis regarding disease severity, we observed this protective effect was confined to proliferative DR (OR=0.4; 95% CI=0.2-0.8) with non-significant effects on the susceptibility of non-proliferative DR (OR=0.67; 95% CI=0.37-1.19).

CONCLUSIONS

We report a protective role of the 12Ala polymorphism against proliferative DR in individuals with T2DM in Pakistan.

摘要

目的

过氧化物酶体增殖物激活受体γ基因第4外显子的非同义替换多态性rs1801282（c.34C>G，p.Pro12Ala）与糖尿病视网膜病变（DR）之间的关联报道并不一致。因此，本研究的目的是了解Pro12Ala多态性在巴基斯坦人群DR易感性中的特定作用。

方法

使用聚合酶链反应-限制性片段长度多态性方法，对180例DR患者、193例无糖尿病视网膜病变的2型糖尿病（T2DM）患者以及200名健康的血糖正常且无视网膜病变的巴基斯坦个体进行rs1801282（c.34C>G）多态性基因分型。

结果

我们发现携带12Ala的T2DM个体发生DR的风险降低（优势比[OR]=0.53；95%置信区间[CI]=0.33 - 0.87）。在按疾病严重程度进行分层分析时，我们观察到这种保护作用仅限于增殖性DR（OR=0.4；95%CI=0.2 - 0.8），对非增殖性DR的易感性无显著影响（OR=0.67；95%CI=0.37 - 1.19）。

结论

我们报道了在巴基斯坦，12Ala多态性对T2DM个体的增殖性DR具有保护作用。