Delgado E A, Malleson P N, Pirie G E, Petty R E
Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Semin Arthritis Rheum. 1990 Apr;19(5):285-93. doi: 10.1016/0049-0172(90)90051-g.
Pleuropulmonary disease in childhood onset SLE is common. It may be insidious or present as a life threatening event. North American Indian children in our population appear to be at high risk for severe lung disease. Pulmonary symptoms are present in the majority of children at some time during their disease course and pulmonary function studies are abnormal in the majority of patients. The pulmonary manifestations and frequency of occurrence in childhood appear to be similar to that described in adult onset SLE. Although pulmonary function studies do not correlate well with pulmonary symptoms, these studies provide objective quantification of the type and severity of the functional lesion. Serial tests may be helpful in monitoring disease activity in childhood SLE.
儿童期起病的系统性红斑狼疮（SLE）合并胸膜肺部疾病很常见。其起病可能隐匿，也可能表现为危及生命的情况。我们研究人群中的北美印第安儿童似乎患严重肺部疾病的风险很高。大多数儿童在病程中的某些时候会出现肺部症状，大多数患者的肺功能检查结果异常。儿童期的肺部表现及发生率似乎与成人起病的SLE中所描述的相似。虽然肺功能检查结果与肺部症状的相关性不佳，但这些检查能对功能性病变的类型和严重程度进行客观量化。系列检查可能有助于监测儿童SLE的疾病活动情况。
