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肠道病毒 117 和 118 的基因组特征：C 组人类肠道病毒中的一个新群组。

Genome characterisation of enteroviruses 117 and 118: a new group within human enterovirus species C.

机构信息

Molecular Virology Unit, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

出版信息

PLoS One. 2013;8(4):e60641. doi: 10.1371/journal.pone.0060641. Epub 2013 Apr 2.

DOI:10.1371/journal.pone.0060641
PMID:23565264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3614900/
Abstract

The more than 120 genotypes of human enteroviruses (HEVs) reflect a wide range of evolutionary divergence, and there are 23 currently classified as human enterovirus C species (HEV-C). Two new HEV-C (EV-C117 and EV-C118) were identified in the Community-Acquired Pneumonia Pediatric Research Initiative (CAP-PRI) study, and the present paper describes the characterisation of the complete genome of one EV-C117 strain (LIT22) and two EV-C118 (ISR38 and ISR10) strains. The EV-C117 and EV-C118 5'UTR sequences were related to those of EV-C104, EV-C105 and EV-C109, and were slightly shorter than those of other HEV A-D species. Similarity plot analyses showed that EV-C117 and EV-C118 have a P1 region that is highly divergent from that of the other HEV-C, and phylogenetic analyses highly supported a monophyletic group consisting of EV-C117, EV-C118, EV-C104, EV-C105 and EV-C109 strains. Phylogenetic, Simplot and Bootscan analyses indicated that recombination was not the main mechanism of EV-C117 and EV-C118 evolution, thus strengthening the hypothesis of the monophyletic origin of the coding regions, as in the case of other HEV-C. Phylogenetic analysis also revealed the emergence of a new group within HEV-C that is divided into two subgroups. Nucleotide and amino acid identity in VP1 sequences have been established as useful criteria for assigning new HEV types, but analysis of the complete P1 region improves resolution.

摘要

人类肠道病毒（HEV）有 120 多种以上基因型，反映出广泛的进化分歧，目前有 23 种被归类为人肠道病毒 C 种（HEV-C）。在社区获得性肺炎儿科研究倡议（CAP-PRI）研究中发现了两种新的 HEV-C（EV-C117 和 EV-C118），本研究描述了一株 EV-C117 株（LIT22）和两株 EV-C118（ISR38 和 ISR10）株的完整基因组特征。EV-C117 和 EV-C118 的 5'UTR 序列与 EV-C104、EV-C105 和 EV-C109 的序列有关，略短于其他 HEV A-D 种的序列。相似性图谱分析表明，EV-C117 和 EV-C118 的 P1 区与其他 HEV-C 高度不同，系统发育分析高度支持由 EV-C117、EV-C118、EV-C104、EV-C105 和 EV-C109 株组成的单系群。系统发育、Simplot 和 Bootscan 分析表明，重组不是 EV-C117 和 EV-C118 进化的主要机制，因此加强了编码区单系起源的假说，就像其他 HEV-C 一样。系统发育分析还揭示了 HEV-C 内出现了一个新的组，分为两个亚组。VP1 序列中的核苷酸和氨基酸同一性已被确立为分配新的 HEV 型的有用标准，但完整 P1 区的分析提高了分辨率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/eda63a76f686/pone.0060641.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/ea2d83d116ce/pone.0060641.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/c545adef5682/pone.0060641.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/e4f7f7fc6785/pone.0060641.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/31a1939db6a8/pone.0060641.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/eda63a76f686/pone.0060641.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/ea2d83d116ce/pone.0060641.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/c545adef5682/pone.0060641.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/e4f7f7fc6785/pone.0060641.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/31a1939db6a8/pone.0060641.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0c1/3614900/eda63a76f686/pone.0060641.g005.jpg

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2
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3
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5
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6
Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016.2016年欧盟/欧洲经济区非脊髓灰质炎肠道病毒的监测与实验室检测
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