Bajaj Sarita, Khan Afreen
Department of Endocrinology, Medicine, MLN Medical College, Allahabad, India.
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S267-71. doi: 10.4103/2230-8210.104057.
Hyperglycemia promotes auto-oxidation of glucose to form free radicals. The generation of free radicals beyond the scavenging abilities of endogenous antioxidant defenses results in macro- and microvascular dysfunction. Antioxidants such as N-acetylcysteine, vitamin C and α-lipoic acid are effective in reducing diabetic complications, indicating that it may be beneficial either by ingestion of natural antioxidants or through dietary supplementation. However, while antioxidants are proving essential tools in the investigation of oxidant stress-related diabetic pathologies and despite the obvious potential merit of a replacement style therapy, the safety and efficacy of antioxidant supplementation in any future treatment, remains to be established.
高血糖会促进葡萄糖的自氧化，从而形成自由基。当自由基的生成超过内源性抗氧化防御机制的清除能力时，就会导致大血管和微血管功能障碍。诸如N-乙酰半胱氨酸、维生素C和α-硫辛酸等抗氧化剂在减少糖尿病并发症方面是有效的，这表明通过摄入天然抗氧化剂或膳食补充剂可能会有益处。然而，尽管抗氧化剂在与氧化应激相关的糖尿病病理研究中被证明是必不可少的工具，而且替代疗法显然有潜在的优点，但抗氧化剂补充剂在未来任何治疗中的安全性和有效性仍有待确定。
