A case for new therapy for diabetes, is it leptin?
作者信息
Kalra Satya P
机构信息
Department of Neuroscience and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA.
出版信息
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 3):S525-8. doi: 10.4103/2230-8210.105566.
Abstract
摘要
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Should leptin replace insulin as a lifetime monotherapy for diabetes type 1 and 2?瘦素能否替代胰岛素作为1型和2型糖尿病的终身单一疗法？
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本文引用的文献
1
Public health: India's diabetes time bomb.公共卫生：印度的糖尿病定时炸弹。
Nature. 2012 May 17;485(7398):S14-6. doi: 10.1038/485s14a.
2
Diabetes in numbers.糖尿病数据
Nature. 2012 May 17;485(7398):S2-3. doi: 10.1038/485s2a.
3
Leptin in human physiology and pathophysiology.瘦素在人类生理学和病理生理学中的作用。
Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E567-84. doi: 10.1152/ajpendo.00315.2011. Epub 2011 Jul 26.
4
Sixteen years and counting: an update on leptin in energy balance.十六年过去了，瘦素在能量平衡中的作用仍在不断更新。
J Clin Invest. 2011 Jun;121(6):2087-93. doi: 10.1172/JCI45888. Epub 2011 Jun 1.
5
Pivotal role of leptin-hypothalamus signaling in the etiology of diabetes uncovered by gene therapy: a new therapeutic intervention?基因治疗揭示瘦素-下丘脑信号在糖尿病发病机制中的关键作用：一种新的治疗干预措施？
Gene Ther. 2011 Apr;18(4):319-25. doi: 10.1038/gt.2010.164. Epub 2011 Jan 6.
6
Neuroendocrine control of energy homeostasis: update on new insights.能量稳态的神经内分泌控制：新见解的更新
Prog Brain Res. 2010;181:17-33. doi: 10.1016/S0079-6123(08)81002-3.
7
Leptin therapy in insulin-deficient type I diabetes.胰岛素缺乏型 1 型糖尿病的瘦素治疗。
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4813-9. doi: 10.1073/pnas.0909422107. Epub 2010 Mar 1.
8
Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation.中枢瘦素基因治疗通过两个独立的下丘脑中继改善 1 型和 2 型糖尿病；除了体重和食欲调节之外的益处。
Peptides. 2009 Oct;30(10):1957-63. doi: 10.1016/j.peptides.2009.07.021. Epub 2009 Aug 6.
9
Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice.中枢性瘦素基因治疗，作为胰岛素治疗的替代方法，可改善高血糖和食欲亢进，并提高胰岛素缺乏型糖尿病小鼠的存活率。
Peptides. 2009 May;30(5):962-6. doi: 10.1016/j.peptides.2009.01.007. Epub 2009 Jan 22.
10
Leptin: a pivotal regulator of human energy homeostasis.瘦素：人体能量平衡的关键调节因子。
Am J Clin Nutr. 2009 Mar;89(3):980S-984S. doi: 10.3945/ajcn.2008.26788C. Epub 2009 Feb 11.
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