Amartey N A A, Nsiah K, Mensah F O
Teaching/Research Assistant, Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology , Kumasi, Ghana .
Senior Lecturer, Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology , Kumasi, Ghana .
J Clin Diagn Res. 2015 Feb;9(2):BC05-9. doi: 10.7860/JCDR/2015/10905.5530. Epub 2015 Feb 1.
Diabetes mellitus is one of the most common metabolic diseases worldwide. This metabolic disorder contributes greatly to the significant proportion of the burden of renal damage and dysfunction. The aim of the study was to investigate the renal function of the diabetic patients who visit the Clinical Analysis Laboratory (CAn-Lab) at the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Demographic data as well as medical history were obtained through the administration of a questionnaire. Anthro-pometric measurements were taken and blood samples were analysed for glucose, uric acid, urea and creatinine. Data collected were analysed using SPSS version 16.0.
A total of 34 diabetic patients, aged from 40-77 y were recruited, 22 (64.7%) of them were males with mean age of 57.40 ± 11.8 y (±SD), while 12 (35.3%) were females with mean age of 58.17 ± 7.47 y. There was a statistically significant difference between the mean duration of the disease, as the females had longer duration, 12.50 ± 6.95 y, as compared to 7.32 ± 4.48 y in males (p=0.033). The mean plasma creatinine level in the females was 84.17 ± 54.73 μmol/l. In the diabetic population, there was a positive correlation between age and plasma creatinine level, (r=0.375, p=0.029). In the female diabetics, there was a positive correlation between fasting blood sugar (FBS) and the measured metabolic end products (r>0.5, p<0.05), a positive correlation between body mass index (BMI) and uric acid (r=0.576, p=0.005) and a positive correlation between BMI and FBS (r= 0.625, p= 0.030).
Our results on the parameters measured; show that the diabetic population was experiencing mild kidney dysfunction, compared to non-diabetic controls.
糖尿病是全球最常见的代谢性疾病之一。这种代谢紊乱在很大程度上导致了肾脏损害和功能障碍负担的很大一部分。本研究的目的是调查前往加纳库马西夸梅·恩克鲁玛科技大学（KNUST）临床分析实验室（CAn-Lab）就诊的糖尿病患者的肾功能。
通过问卷调查获取人口统计学数据以及病史。进行人体测量，并对血液样本进行葡萄糖、尿酸、尿素和肌酐分析。使用SPSS 16.0版对收集的数据进行分析。
共招募了34名年龄在40 - 77岁的糖尿病患者，其中22名（64.7%）为男性，平均年龄为57.40±11.8岁（±标准差），而12名（35.3%）为女性，平均年龄为58.17±7.47岁。疾病平均病程存在统计学显著差异，女性病程较长，为12.50±6.95年，而男性为7.32±4.48年（p = 0.033）。女性的平均血浆肌酐水平为84.17±54.73μmol/l。在糖尿病患者群体中，年龄与血浆肌酐水平呈正相关（r = 0.375，p = 0.029）。在女性糖尿病患者中，空腹血糖（FBS）与所测代谢终产物呈正相关（r>0.5，p<0.05），体重指数（BMI）与尿酸呈正相关（r = 0.576，p = 0.005），BMI与FBS呈正相关（r = 0.625，p = 0.030）。
我们对所测参数的研究结果表明，与非糖尿病对照组相比，糖尿病患者群体正经历轻度肾功能障碍。
