Tsai Minglun, Asakawa Akihiro, Amitani Haruka, Inui Akio
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 3):S543-8. doi: 10.4103/2230-8210.105570.
Leptin has a crucial role in regulating food intake and maintaining metabolic homeostasis. Although little is known about the process of leptin secretion, insulin, which has an important role in the metabolism of glucose and lipids, is believed to regulate leptin secretion through a posttranscriptional mechanism in the short term, and via glucose metabolism in the long term. The gastric mucosa secretes leptin, but this mechanism has not been completely elucidated. Understanding the mechanism of insulin-regulated leptin secretion could lead to the development of new treatment methods for obesity and its comorbidities, which are serious public health concerns.
瘦素在调节食物摄入和维持代谢稳态方面发挥着关键作用。尽管对瘦素分泌过程了解甚少，但胰岛素在葡萄糖和脂质代谢中起重要作用，据信它在短期内通过转录后机制调节瘦素分泌，长期则通过葡萄糖代谢进行调节。胃黏膜会分泌瘦素，但其机制尚未完全阐明。了解胰岛素调节瘦素分泌的机制可能会促成针对肥胖及其合并症的新治疗方法的开发，而肥胖及其合并症是严重的公共卫生问题。
