镍催化的亚胺和炔烃或降冰片烯的[2+2+1]羰基环加成反应生成γ-内酰胺。
Nickel(0)-catalyzed [2 + 2 + 1] carbonylative cycloaddition of imines and alkynes or norbornene leading to γ-lactams.
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
出版信息
J Am Chem Soc. 2014 Nov 12;136(45):15877-80. doi: 10.1021/ja509171a. Epub 2014 Nov 4.
PMID:25354361
Abstract
The first nickel(0)-catalyzed [2 + 2 + 1] carbonylative cycloaddition reaction of imines and alkynes or norbornene has been achieved by employing phenyl formate as a CO source. With this method, a variety of N-benzenesulfonyl, -tosyl, and -phosphoryl-substituted γ-lactams can be prepared in good to high yields.
摘要
首例镍(0)催化的亚胺与炔烃或降冰片烯的[2 + 2 + 1]羰基环加成反应已经实现，该反应采用甲酸苯酯作为 CO 源。使用这种方法，可以以良好到较高的收率制备各种 N-苯磺酰基、-甲苯磺酰基和-膦酰基取代的γ-内酰胺。
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