24 种尼日利亚传统药用植物的体外抗癌筛选
In vitro anticancer screening of 24 locally used Nigerian medicinal plants.
机构信息
Department of Biological Sciences, Tennessee State University, 3500 John A, Merritt Blvd, Nashville, TN 37217, USA.
出版信息
BMC Complement Altern Med. 2013 Apr 8;13:79. doi: 10.1186/1472-6882-13-79.
BACKGROUND
Plants that are used as traditional medicine represent a relevant pool for selecting plant candidates that may have anticancer properties. In this study, the ethnomedicinal approach was used to select several medicinal plants native to Nigeria, on the basis of their local or traditional uses. The collected plants were then evaluated for cytoxicity.
METHODS
The antitumor activity of methanolic extracts obtained from 24 of the selected plants, were evaluated in vitro on five human cancer cell lines.
RESULTS
Results obtained from the plants screened indicate that 18 plant extracts of folk medicine exhibited promising cytotoxic activity against human carcinoma cell lines. Erythrophleum suaveolens (Guill. & Perr.) Brenan was found to demonstrate potent anti-cancer activity in this study exhibiting IC(50) = 0.2-1.3 μg/ml.
CONCLUSIONS
Based on the significantly potent activity of some plants extracts reported here, further studies aimed at mechanism elucidation and bio-guided isolation of active anticancer compounds is currently underway.
背景
被用作传统药物的植物是选择具有抗癌特性的植物候选物的重要来源。在这项研究中，根据其当地或传统用途，采用民族医学方法选择了几种原产于尼日利亚的药用植物。然后对收集的植物进行细胞毒性评估。
方法
从 24 种选定植物中获得的甲醇提取物的抗肿瘤活性在体外对五种人癌细胞系进行了评估。
结果
从筛选的植物中获得的结果表明，18 种民间药物的植物提取物对人癌细胞系表现出有希望的细胞毒性活性。在这项研究中，发现 Erythrophleum suaveolens（Guill. & Perr.）Brenan 具有很强的抗癌活性，IC（50）为 0.2-1.3 μg/ml。
结论
基于此处报道的一些植物提取物的显著有效活性，目前正在进行旨在阐明机制和生物导向分离活性抗癌化合物的进一步研究。
Zotero 插件