miRNA-92b 调控胚胎鼠大脑中间皮质祖细胞的发育。
MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain.
机构信息
Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7056-61. doi: 10.1073/pnas.1219385110. Epub 2013 Apr 8.
Abstract
Cerebral cortical neurons arise from radial glia (direct neurogenesis) or from intermediate progenitors (indirect neurogenesis); intriguingly, the sizes of intermediate progenitor populations and the cortices they generate correlate across species. The generation of intermediate progenitors is regulated by the transcription factor Tbr2, whose expression marks these cells. We investigated how this mechanism might be controlled. We found that acute blockade of mature microRNA biosynthesis in murine cortical progenitors caused a rapid cell autonomous increase in numbers of Tbr2-expressing cells. Acute microRNA-92b (miR-92b) gain of function caused rapid reductions in numbers of Tbr2-expressing cells and proliferating intermediate progenitors. Acute miR-92b loss of function had opposite effects. These findings indicate that miR-92b limits the production of intermediate cortical progenitors.
摘要
大脑皮层神经元由放射状胶质细胞（直接神经发生）或中间祖细胞（间接神经发生）产生；有趣的是，中间祖细胞群体的大小及其产生的皮质在物种间相关。中间祖细胞的产生受转录因子 Tbr2 的调节，其表达标志着这些细胞。我们研究了这种机制可能是如何被控制的。我们发现，急性阻断小鼠皮质祖细胞中成熟 microRNA 生物合成会导致 Tbr2 表达细胞数量的快速自主增加。急性 microRNA-92b（miR-92b）功能获得会导致 Tbr2 表达细胞和增殖中间祖细胞的数量迅速减少。急性 miR-92b 功能丧失则有相反的效果。这些发现表明，miR-92b 限制了中间皮质祖细胞的产生。
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