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髋部骨折高危患者骨质疏松症的诊断与治疗

Diagnosis and treatment of osteoporosis in high-risk patients prior to hip fracture.

作者信息

Gleason Lauren J, Menzies Isaura B, Mendelson Daniel A, Kates Stephen L, Friedman Susan M

机构信息

Department of Medicine, Division of Geriatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

出版信息

Geriatr Orthop Surg Rehabil. 2012 Jun;3(2):79-83. doi: 10.1177/2151458512454878.

Abstract

PURPOSE

Hip fractures in older adults are common and serious events. Patients who sustain fragility hip fractures are defined as having osteoporosis. Patients with dementia or a history of a prior fragility fracture are at increased risk of a future fracture. This study assesses prefracture osteoporosis diagnosis and treatment in high-risk groups.

METHODS

A case-control analysis of a database of all patients age ≥60 years admitted for surgical repair of nonpathological, low-impact femur fracture between May 2005 and October 2010 was performed.

RESULTS

Of 1070 patients, 511 (47.8%) had dementia and 435 (40.7%) had been diagnosed with osteoporosis prior to admission. Patients with dementia were more likely to have a diagnosis of osteoporosis prior to their fracture than those without dementia (43.8% vs 37.7%, P < .05). Twenty-five percent of the total study population had been treated with calcium and vitamin D (Cal+D) prior to admission, and 12% with other osteoporosis medications. There was a trend toward patients with dementia being more likely to have been on Cal+D prior to admission (27.6% vs 22.5%, P = .06), but no difference in treatment with other agents (10.8% vs 13.1%, P = .25). Patients with prior fragility fractures were more likely to be on Cal+D (32.3% vs 25.0%, P < .02); however, there was no difference in the use of other osteoporosis medications (12.3% vs 12%, P = .90).

CONCLUSION

Fewer than half of patients that presented with hip fractures were diagnosed with osteoporosis prior to fracture and primary preventative treatment rates were low. Although patients with dementia are more likely to be diagnosed with osteoporosis, they were not more likely to be treated, despite having a greater risk. Additionally, those with prior fragility fractures are often not on preventative treatment. This may represent a missed opportunity for prevention and room for improvement in order to reduce osteoporotic hip fractures.

摘要

目的

老年人髋部骨折是常见且严重的事件。发生脆性髋部骨折的患者被定义为患有骨质疏松症。患有痴呆症或有既往脆性骨折病史的患者未来发生骨折的风险增加。本研究评估高危人群骨折前骨质疏松症的诊断和治疗情况。

方法

对2005年5月至2010年10月期间因非病理性、低暴力性股骨骨折接受手术修复而入院的所有年龄≥60岁患者的数据库进行病例对照分析。

结果

在1070例患者中,511例(47.8%)患有痴呆症,435例(40.7%)在入院前被诊断为骨质疏松症。与没有痴呆症的患者相比,患有痴呆症的患者在骨折前更有可能被诊断为骨质疏松症(43.8%对37.7%,P<.05)。在入院前,25%的总研究人群接受过钙和维生素D(Cal+D)治疗,12%接受过其他骨质疏松症药物治疗。患有痴呆症的患者在入院前更有可能接受Cal+D治疗,存在一种趋势(27.6%对22.5%,P=.06),但在接受其他药物治疗方面没有差异(10.8%对13.1%,P=.25)。有既往脆性骨折病史的患者更有可能接受Cal+D治疗(32.3%对25.0%,P<.02);然而,在使用其他骨质疏松症药物方面没有差异(12.3%对12%,P=.90)。

结论

髋部骨折患者中不到一半在骨折前被诊断为骨质疏松症,一级预防治疗率较低。尽管患有痴呆症的患者更有可能被诊断为骨质疏松症,但尽管风险更大,他们接受治疗的可能性并不更高。此外,有既往脆性骨折病史的患者通常未接受预防性治疗。这可能意味着存在预防机会的错失以及为减少骨质疏松性髋部骨折而有待改进的空间。

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