Arokiyaraj S, Balamurugan R, Augustian P
Department of PG and Research, Sathyabama University, Chennai-119, India.
Asian Pac J Trop Biomed. 2011 Oct;1(5):386-90. doi: 10.1016/S2221-1691(11)60085-3.
To evaluate the antihyperglycemic activity of ethyl acetate extract of Hypericum perforatum (H. perforatum) in streptozotocin (STZ)-induced diabetic rats.
Acute toxicity and oral glucose tolerance test were performed in normal rats. Male albino rats were rendered diabetic by STZ (40 mg/kg, intraperitoneally). H. perforatum ethyl acetate extract was orally administered to diabetic rats at 50, 100 and 200 mg/kg doses for 15 days to determine the antihyperglycemic activity. Biochemical parameters were determined at the end of the treatment.
H. perforatum ethyl acetate extract showed dose dependant fall in fasting blood glucose (FBG). After 30 min of extract administration, FBG was reduced significantly when compared with normal rats. H. perforatum ethyl acetate extract produced significant reduction in plasma glucose level, serum total cholesterol, triglycerides, glucose-6-phosphatase levels. Tissue glycogen content, HDL-cholesterol, glucose-6-phosphate dehydrogenase were significantly increased compared with diabetic control. No death or lethal effect was observed in the toxic study.
The results demonstrate that H. perforatum ethyl acetate extract possesses potent antihyperglycemic activity in STZ induced diabetic rats.
评估贯叶连翘乙酸乙酯提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖活性。
对正常大鼠进行急性毒性试验和口服葡萄糖耐量试验。雄性白化病大鼠通过腹腔注射STZ（40mg/kg）诱导糖尿病。将贯叶连翘乙酸乙酯提取物以50、100和200mg/kg的剂量口服给予糖尿病大鼠15天，以确定其降血糖活性。在治疗结束时测定生化参数。
贯叶连翘乙酸乙酯提取物显示出空腹血糖（FBG）的剂量依赖性下降。提取物给药30分钟后，与正常大鼠相比，FBG显著降低。贯叶连翘乙酸乙酯提取物使血浆葡萄糖水平、血清总胆固醇、甘油三酯、葡萄糖-6-磷酸酶水平显著降低。与糖尿病对照组相比，组织糖原含量、高密度脂蛋白胆固醇、葡萄糖-6-磷酸脱氢酶显著增加。在毒性研究中未观察到死亡或致死效应。
结果表明，贯叶连翘乙酸乙酯提取物对STZ诱导的糖尿病大鼠具有有效的降血糖活性。
