CEC School of Pharmacy, Lal Khadan, Masturi Road, Bilaspur (CG) India.
Asian Pac J Trop Med. 2011 Jan;4(1):20-3. doi: 10.1016/S1995-7645(11)60025-4. Epub 2011 Jan 15.
To evaluate antidiabetic activity of chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinispora cordifolia stem, Ocimum sanctum areal parts and Jatropha curcus leaves.
The chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinospora cordifolia stem, aerial part of Ocimum sanctum and Jatropha curcus leaves were evaluated at different doses (250 and 500 mg/kg body weight.) for antidiabetic potentials in alloxan induced diabetic albino rats. The extracts were administered for two weeks in different groups whereas tolbutamide (80 mg/kg body weight) was used as reference standard throughout study.
The result of present study showed test compounds significantly decreases elevated level of serum glucose and also caused to reverse the cholesterol, triglyceride, HDL and LDL values when compared to untreated diabetic rats.
Our finding indicates that different test extracts were able to ameliorate the derangements in lipid metabolism caused by diabetes mellitus in alloxan induced diabetic rats towards normal level.
评价阿拉伯金合欢树皮、冬瓜果实、鸡血藤茎、圣罗勒地上部分和麻疯树叶的氯仿提取物的降血糖活性。
用不同剂量（250 和 500 mg/kg 体重）评价阿拉伯金合欢树皮、冬瓜果实、鸡血藤茎、圣罗勒地上部分和麻疯树叶的氯仿提取物在四氧嘧啶诱导的糖尿病白化大鼠中的降血糖潜力。在不同组中给予提取物两周，而甲苯磺丁脲（80 mg/kg 体重）在整个研究过程中用作参考标准。
本研究结果表明，与未治疗的糖尿病大鼠相比，测试化合物可显著降低血清葡萄糖水平，并可逆转胆固醇、甘油三酯、HDL 和 LDL 值。
我们的发现表明，不同的测试提取物能够改善四氧嘧啶诱导的糖尿病大鼠的脂代谢紊乱，使其恢复正常水平。
