Lilienfeld D E, Chan E, Ehland J, Godbold J, Landrigan P J, Marsh G, Perl D P
Department of Community Medicine, Mount Sinai School of Medicine, New York, NY 10029.
Arch Neurol. 1990 Jul;47(7):731-4. doi: 10.1001/archneur.1990.00530070019005.
To examine the possible role of environmental factors in the cause of Parkinson's disease (PD), we reviewed mortality trends for PD in the United States from 1962 through 1984. We found that age-specific mortality for PD in all demographic groups had changed notably during this 23-year interval. Among whites of both sexes, substantial declines were observed among the middle-aged, while notable increases were seen in the geriatric age groups. Similar changes were found in nonwhites; among nonwhites in the geriatric age range, increases of 22% to 553% were observed among women. Men generally had a 100% higher risk of death due to PD than did women. Whites were at three times the risk of nonwhites. The observed temporal changes appear to reflect improved treatment, better case ascertainment, and a true rise in the incidence of PD, particularly among the elderly. This rise may be due to preventable environmental causes and will require further investigation.
为研究环境因素在帕金森病（PD）病因中可能发挥的作用，我们回顾了1962年至1984年美国PD的死亡率趋势。我们发现，在这23年期间，所有人口群体中按年龄划分的PD死亡率都有显著变化。在两性白人中，中年人死亡率大幅下降，而老年人群体中死亡率显著上升。非白人也有类似变化；在老年非白人女性中，死亡率上升了22%至553%。男性因PD死亡的风险通常比女性高100%。白人患PD的风险是非白人的三倍。观察到的时间变化似乎反映了治疗改善、病例确诊更好以及PD发病率的真实上升，尤其是在老年人中。这种上升可能是由可预防的环境因素导致的，需要进一步调查。
