Medical School, Doorway 3, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Clin Transl Allergy. 2013 Apr 10;3(1):14. doi: 10.1186/2045-7022-3-14.
The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management and impact on quality of life, which will be used to inform clinical recommendations.The aims of this systematic review will be to assess the effectiveness of interventions for the acute management of anaphylaxis, and pharmacological and non-pharmacological approaches for the long-term management of anaphylaxis.
A highly sensitive search strategy has been developed, and validated study design filters will be applied to retrieve all articles pertaining to the management of anaphylaxis from electronic bibliographic databases. We will systematically review the literature on the acute management of anaphylaxis by assessing the effectiveness of epinephrine, H1-antihistamines (versus placebo), systemic glucocorticosteroids, methylxanthines or any other treatments for the emergency management of people experiencing anaphylaxis. The main interventions that have been studied in the context of long-term management are anaphylaxis management plans and allergen-specific immunotherapy.
There is at present little in the way of robust evidence to guide decisions on the acute and/or long-term management of anaphylaxis. Given the risk of death and the considerable morbidity associated with anaphylaxis these evidence gaps need to be filled wherever possible; this systematic review will make a start in this area.
欧洲过敏与临床免疫学会正在制定食物过敏和过敏反应指南，这是为了提供有关流行病学、预防、诊断和临床管理以及对生活质量的影响的最新证据基础的综合摘要而进行的七个相互关联的证据综合分析之一，这些综合分析将用于为临床建议提供信息。本系统评价的目的将是评估急性过敏反应管理的干预措施的有效性，以及过敏反应的长期管理的药理学和非药理学方法。
制定了高度敏感的搜索策略，并将应用经过验证的研究设计筛选器从电子书目数据库中检索与过敏反应管理相关的所有文章。我们将通过评估肾上腺素、H1 抗组胺药（与安慰剂相比）、全身糖皮质激素、黄嘌呤或任何其他用于管理过敏反应的紧急管理的治疗方法，对过敏反应的急性管理进行系统综述。在长期管理方面研究的主要干预措施是过敏反应管理计划和过敏原特异性免疫疗法。
目前几乎没有可靠的证据来指导过敏反应的急性和/或长期管理决策。鉴于过敏反应导致死亡和严重发病率的风险，需要尽可能填补这些证据空白；本系统评价将在这方面开始。
