University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Clin Transl Allergy. 2013 May 1;3(1):15. doi: 10.1186/2045-7022-3-15.
The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management, and impact on quality of life, which will be used to inform clinical recommendations. The aim of this systematic review will be to determine which validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, food allergy on health-related quality of life.
Seven bibliographic databases were searched from their inception to September 30, 2012 for disease-specific HRQL questionnaires that were specifically designed for use with patients/carers and any articles relating to the description, development and/or the validation of the above identified HRQLs. There were no language or geographic restrictions. We will assess the development of the instruments identified and their performance properties including: validity; generalizability; responsiveness; managing missing data; how variation in patient demography was managed; and cross-cultural and linguistic adaptation, using a previously reported quality assessment tool.
Using appropriately developed and validated instruments is critical to the accurate evaluation of HRQL in people with food allergy. This review will systematically appraise the evidence on the subject and help to identify any gaps.
欧洲过敏与临床免疫学会正在制定食物过敏和过敏反应指南，本系统评价是为了提供当前流行病学、预防、诊断和临床管理以及对生活质量的影响方面的最新证据基础而进行的七个相互关联的证据综合分析之一，这些证据将用于为临床建议提供信息。本系统评价的目的将是确定可以使用哪些经过验证的工具来评估食物过敏对健康相关生活质量的影响、调查和干预措施。
从 2012 年 9 月 30 日开始，对七个文献数据库进行了搜索，以寻找专门为患者/照顾者设计的特定用于评估食物过敏对健康相关生活质量影响的疾病特异性 HRQL 问卷，以及任何与上述 HRQL 描述、开发和/或验证相关的文章。无语言或地理限制。我们将评估所确定的工具的开发及其性能特性，包括：有效性；通用性；响应性；处理缺失数据；如何管理患者人口统计学差异；以及跨文化和语言适应性，使用以前报道的质量评估工具。
使用适当开发和验证的工具对于准确评估食物过敏患者的 HRQL 至关重要。本综述将系统地评估这一主题的证据，并帮助确定任何差距。
