Division of Chest Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Inflammation. 2013 Oct;36(5):1013-9. doi: 10.1007/s10753-013-9633-z.
Hydrogen peroxide (H(2)O(2)) is a highly reactive oxygen species involved in lung and bronchial epithelium injury. Increased H(2)O(2) levels have been reported in expired breath condensates of patients with inflammatory airway diseases such as chronic obstructive pulmonary disease. Protecting airway epithelial cells from oxidative stress is an important task in the prevention and management of airway diseases. Previous studies demonstrate that yam (Dioscorea batatas Decne) has antioxidant and anti-trypsin activities. This study evaluated the validity of dioscorin in vitro. The results showed that dioscorin attenuated the alteration of H(2)O(2) on G2/M cell cycle arrest. This might be associated with the activation of IκB and subsequent inactivation of NF-κB. Furthermore, dioscorin suppressed IL-8 secretion and reduced changes of adhesion molecule expressions in H(2)O(2)-injured A549 cells. These results help in understanding the potential of traditional Chinese herbal medicine as treatment for airway inflammatory diseases.
过氧化氢（H2O2）是一种高度活跃的氧自由基，参与肺和支气管上皮细胞的损伤。在慢性阻塞性肺疾病等炎症性气道疾病患者的呼出气冷凝物中，已报告 H2O2 水平升高。保护气道上皮细胞免受氧化应激是预防和管理气道疾病的重要任务。先前的研究表明，山药（Dioscorea batatas Decne）具有抗氧化和抗胰蛋白酶活性。本研究评估了薯蓣皂素在体外的有效性。结果表明，薯蓣皂素可减轻 H2O2 对 G2/M 细胞周期阻滞的改变。这可能与 IκB 的激活和随后 NF-κB 的失活有关。此外，薯蓣皂素抑制 IL-8 的分泌，并减少 H2O2 损伤的 A549 细胞中黏附分子表达的变化。这些结果有助于理解传统中药作为治疗气道炎症性疾病的潜力。
