小脑在感觉和运动皮层的γ波段同步中的功能作用。
Functional role of the cerebellum in gamma-band synchronization of the sensory and motor cortices.
机构信息
Ecole Normale Supérieure, Institut de Biologie de l'ENS, IBENS, INSERM, U1024, and CNRS, UMR 8197, F-75005 Paris, France.
出版信息
J Neurosci. 2013 Apr 10;33(15):6552-6. doi: 10.1523/JNEUROSCI.5521-12.2013.
Abstract
The cerebellum is an essential structure for the control of movement. It sends abundant ascending projections to the cerebral cortex via the thalamus, but its contribution to cortical activity remains largely unknown. Here we studied its influence on cortical neuronal activity in freely moving rats. We demonstrate an excitatory action of the cerebellum on the motor thalamus and the motor cortex. We also show that cerebellar inactivation disrupts the gamma-band coherence of local field potential between the sensory and motor cortices during whisking. In contrast, phase locking of neuronal activities to local gamma oscillations was preserved in the sensory and motor cortices by cerebellar inactivation. These results indicate that the cerebellum contributes to coordinated sensorimotor cortical activities during motor activation and thus participates in the multiregional cortical processing of information.
摘要
小脑是运动控制的重要结构。它通过丘脑向大脑皮层发送丰富的上行投射，但小脑对皮层活动的贡献在很大程度上仍不清楚。在这里，我们研究了小脑在自由活动大鼠皮层神经元活动中的影响。我们证明了小脑对运动丘脑和运动皮层的兴奋作用。我们还表明，小脑失活破坏了在刷动过程中感觉和运动皮层之间局部场电位的γ 波段相干性。相比之下，小脑失活保留了感觉和运动皮层中神经元活动与局部γ 振荡的相位锁定。这些结果表明，小脑有助于运动激活期间感觉运动皮层的协调活动，从而参与信息的多区域皮层处理。
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PLoS One. 2012;7(9):e44560. doi: 10.1371/journal.pone.0044560. Epub 2012 Sep 5.
2
Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks.解析小脑通路，实现高时间精度的运动靶向，以及广泛的感觉和顶叶网络。
Nat Commun. 2012 Jun 26;3:924. doi: 10.1038/ncomms1912.
3
The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes.细胞外场和电流的起源——EEG、ECoG、LFP 和 spikes。
Nat Rev Neurosci. 2012 May 18;13(6):407-20. doi: 10.1038/nrn3241.
4
Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.抑制性中间神经元缺失与阿尔茨海默病模型中的网络活动改变和认知功能障碍有关。
Cell. 2012 Apr 27;149(3):708-21. doi: 10.1016/j.cell.2012.02.046.
5
Neuronal basis for object location in the vibrissa scanning sensorimotor system.触须扫描感觉运动系统中物体位置的神经元基础。
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6
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Front Integr Neurosci. 2011 Oct 4;5:53. doi: 10.3389/fnint.2011.00053. eCollection 2011.
7
Long-range neuronal circuits underlying the interaction between sensory and motor cortex.感觉皮层和运动皮层相互作用的长程神经元回路。
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8
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9
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10
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