天然反义转录本的生物学功能。
Biological functions of natural antisense transcripts.
机构信息
RNA Interest Group, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, UK.
出版信息
BMC Biol. 2013 Apr 12;11:31. doi: 10.1186/1741-7007-11-31.
In theory, the human genome is large enough to keep its roughly 20,000 genes well separated. In practice, genes are clustered; even more puzzling, in many cases both DNA strands of a protein coding gene are transcribed. The resulting natural antisense transcripts can be a blessing and curse, as many appreciate, or simply transcriptional trash, as others believe. Widespread evolutionary conservation, as recently demonstrated, is a good indicator for potential biological functions of natural antisense transcripts.
从理论上讲，人类基因组足够大，可以将其大约 20000 个基因很好地分隔开。实际上，基因是聚集在一起的；更令人困惑的是，在许多情况下，蛋白质编码基因的两条 DNA 链都被转录。由此产生的自然反义转录本可能是一种祝福，也可能是一种诅咒，正如许多人所欣赏的那样，或者正如其他人所认为的那样，只是转录垃圾。最近的研究表明，广泛的进化保守性是自然反义转录本具有潜在生物学功能的良好指标。
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