Chen J Z, Stall A M, Herzenberg L A, Herzenberg L A
Department of Genetics, Stanford University School of Medicine, CA 94305.
EMBO J. 1990 Jul;9(7):2117-24. doi: 10.1002/j.1460-2075.1990.tb07380.x.
Studies presented here demonstrate that IgM and IgD molecules on normal murine B lymphocytes exist in different, noncovalently associated molecular complexes containing distinct but potentially related glycoproteins. The glycoproteins in these complexes, particularly those associated with IgD, show striking differences in various lymphoid organs and in X-linked immunodeficient (Xid) mice. These differences are due in part to post-translational processing. They apparently reflect the differential expression of the Ig-associated glycoproteins in the various B cell subpopulations and lineages and the differential distribution of the subpopulations and lineages in the various lymphoid organs. In addition, they reflect structural differences in the IgM and IgD complexes which, we suggest, permit differential signal transduction by IgM and IgD on the same B cell.
此处展示的研究表明，正常鼠类B淋巴细胞上的IgM和IgD分子存在于不同的、非共价结合的分子复合物中，这些复合物包含不同但可能相关的糖蛋白。这些复合物中的糖蛋白，尤其是与IgD相关的糖蛋白，在各种淋巴器官以及X连锁免疫缺陷（Xid）小鼠中表现出显著差异。这些差异部分归因于翻译后加工。它们显然反映了Ig相关糖蛋白在各种B细胞亚群和谱系中的差异表达，以及这些亚群和谱系在各种淋巴器官中的差异分布。此外，它们反映了IgM和IgD复合物的结构差异，我们认为，这种差异使得同一B细胞上的IgM和IgD能够进行差异信号转导。
