Institute for Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, Pavillion Marcelle-Coutu, Chemin Polytechnique, Montréal, Québec H3T 1J4, Canada.
Trends Cell Biol. 2013 Jul;23(7):328-35. doi: 10.1016/j.tcb.2013.03.004. Epub 2013 Apr 10.
mRNA export is a critical step in gene expression. Export of transcripts can be modulated in response to cellular signaling or stress. Consistently, mRNA export is dysregulated in primary human specimens derived from many different forms of cancer. Aberrant expression of export factors can alter the export of specific transcripts encoding proteins involved in proliferation, survival, and oncogenesis. These specific factors, which are not used for bulk mRNA export, are obvious therapeutic targets. Indeed, given the emerging role of mRNA export in cancer, it is not surprising that efforts to target different aspects of this pathway have reached the clinical trial stage. Thus, like transcription and translation, mRNA export may also play a critical role in cancer genesis and maintenance.
mRNA 输出是基因表达的关键步骤。转录本的输出可以响应细胞信号或应激进行调节。一致地，mRNA 输出在源自许多不同形式癌症的原发性人类标本中失调。输出因子的异常表达可以改变参与增殖、存活和肿瘤发生的特定蛋白质编码转录本的输出。这些特定的因子不用于批量 mRNA 输出，是明显的治疗靶点。事实上，鉴于 mRNA 输出在癌症中的新兴作用，靶向该途径的不同方面的努力已经进入临床试验阶段也就不足为奇了。因此，与转录和翻译一样，mRNA 输出也可能在癌症的发生和维持中发挥关键作用。
