Gilbertson Rebecca, Prather Robert, Nixon Sara Jo
Division of Clinical Addiction Research, Department of Psychiatry, University of Florida, Gainesville, Florida.
Alcohol Res Health. 2008;31(4):389-99.
Gender, family history, comorbid psychiatric and substance use disorders, and age all influence a person's risk for alcoholism. In addition, these factors interact with alcoholism to influence neurocognitive functioning following detoxification. This article examines these factors and considers how they interact with each other. This complexity reinforces the need for both animal and human studies and suggests multiple factors that may be sensitive to differential prevention, intervention, and treatment efforts. Thus, it is imperative that hypothesis-driven research designs be directed to identifying the relative potency of these factors and their interactions.
性别、家族病史、共病的精神疾病和物质使用障碍以及年龄都会影响一个人患酒精中毒的风险。此外，这些因素与酒精中毒相互作用，影响解毒后的神经认知功能。本文探讨了这些因素，并考虑了它们之间的相互作用方式。这种复杂性凸显了进行动物研究和人体研究的必要性，并提示了多个可能对不同的预防、干预和治疗措施敏感的因素。因此，必须采用以假设为驱动的研究设计来确定这些因素及其相互作用的相对影响力。
