Department of Pneumonology, Arny General Hospital of Athens, Athens, Greece;
J Thorac Dis. 2013 Apr;5(2):E21-4. doi: 10.3978/j.issn.2072-1439.2012.06.03.
Metastasis to the thyroid gland is uncommon compared with the frequency of primary thyroid tumors. The primary sites of metastatic thyroid tumors usually include the breast, lung, kidney and stomach. Among lung cancer types metastasizing to the thyroid, adenocarcinomas are the commonest followed by squamous and large cell carcinomas. Small cell lung carcinoma has not been frequently reported to cause thyroid metastatic deposits. Herein, we describe a patient with small cell lung cancer who developed metastatic lesions to the thyroid and brain simultaneously. Thyroid ultrasonography-guided fine-needle aspiration cytology (US-FNAC) and particularlyimmunocytochemistry documented metastasis from primary lung cancer. Clinical, cytopathological and therapeutic aspects of this unusual site of extrathoracic metastatic disease are discussed laying special emphasis on the paramount importance of the immunocytochemistry in distinguishing primary thyroid tumors from thyroid metastasis due to lung cancer.
与原发性甲状腺肿瘤的频率相比，甲状腺转移较为罕见。转移性甲状腺肿瘤的原发部位通常包括乳腺、肺、肾和胃。在转移至甲状腺的肺癌类型中，腺癌最为常见，其次是鳞状细胞癌和大细胞癌。小细胞肺癌很少引起甲状腺转移灶。在此，我们描述了一例小细胞肺癌患者，其同时发生甲状腺和脑部转移病灶。甲状腺超声引导下细针抽吸细胞学检查（US-FNAC），特别是免疫细胞化学检查，证实了原发性肺癌的转移。本文讨论了这种非胸部远处转移疾病的罕见部位的临床、细胞病理学和治疗方面，特别强调了免疫细胞化学在鉴别原发性甲状腺肿瘤与肺癌引起的甲状腺转移方面的重要性。
