Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
BMC Biol. 2013 Apr 15;11:38. doi: 10.1186/1741-7007-11-38.
The fruit fly Drosophila has contributed significantly to our general understanding of the basic principles of signaling, cell and developmental biology, and neurobiology. However, answers to questions pertaining to energy metabolism have been so far mostly addressed in more complex model organisms such as mice. We review in this article recent studies that show how the genetic tractability and simplicity of Drosophila are being used to identify novel regulatory mechanisms at the organismal level, and to query the co-ordination between energy metabolism and other processes such as neurodegeneration, circadian rhythms, immunity, and tumor biology.
果蝇在帮助我们理解信号转导、细胞和发育生物学以及神经生物学的基本原理方面发挥了重要作用。然而，有关能量代谢的问题的答案迄今为止主要是在更复杂的模式生物如老鼠中得到解答。我们在本文中综述了最近的研究，这些研究表明，果蝇的遗传易处理性和简单性如何被用来在机体水平上鉴定新的调控机制，并探究能量代谢与神经退行性变、昼夜节律、免疫和肿瘤生物学等其他过程的协调。
