College of Materials Science and Engineering, Sichuan University, Chengdu 610064, PR China.
Int Immunopharmacol. 2013 Jun;16(2):214-23. doi: 10.1016/j.intimp.2013.04.001. Epub 2013 Apr 12.
Angiogenesis is a key component of bone formation. Delivery of growth factors for both angiogenesis and osteogenesis is about to gain important potential as a future therapeutic tool. This review focuses on these growth factors that have dual functions in angiogenesis and osteogenesis, and their localized application. A major hurdle in the clinical development of growth factor therapy so far is how to assure safe and efficacious therapeutic use of such factors and avoid unwanted side effects and toxicity. It is now firmly established from the available information that the type, dose, combinations and delivery kinetics of growth factors all play a decisive role for the success of growth factor therapy. All of these parameters have to be adapted and optimized for each animal model or clinical case. In this review we discuss some important parameters associated with growth factor therapy and present an overview of selected preclinical studies, followed by a conceptual description of both established and proposed delivery strategies meeting therapeutic needs.
血管生成是骨形成的关键组成部分。用于血管生成和成骨的生长因子的传递即将作为未来的治疗工具获得重要潜力。本综述重点介绍了这些在血管生成和成骨中具有双重功能的生长因子及其局部应用。迄今为止，生长因子治疗的临床发展中的一个主要障碍是如何确保此类因子的安全有效治疗用途，并避免不必要的副作用和毒性。现有资料明确表明，生长因子的类型、剂量、组合和传递动力学对于生长因子治疗的成功都起着决定性的作用。所有这些参数都必须针对每个动物模型或临床病例进行调整和优化。在本综述中，我们讨论了与生长因子治疗相关的一些重要参数，并概述了选定的临床前研究，随后对满足治疗需求的既定和提出的传递策略进行了概念性描述。
