Theoretical Biology Unit, Department of Biology, University of Rouen, 76821 Mont Saint Aignan cedex, France.
Res Microbiol. 2013 Sep;164(7):779-87. doi: 10.1016/j.resmic.2013.04.003. Epub 2013 Apr 12.
Many bacterial genes are in operons and the process whereby operons are formed is therefore fundamental. To help elucidate this process, we propose in the Scribbling Pad hypothesis that bacteria have been constantly using plasmids for genetic experimentation and, in particular, for the construction of operons. This hypothesis simultaneously solves the problems of the creation of operons and the way operons are propagated. We cite results in the literature to support the hypothesis and make experimental predictions to test it.
许多细菌基因都在操纵子中，因此操纵子的形成过程是非常基础的。为了帮助阐明这一过程，我们在“涂鸦垫假说”中提出，细菌一直在利用质粒进行基因实验，特别是构建操纵子。该假说同时解决了操纵子的形成和操纵子传播的问题。我们引用文献中的结果来支持该假说，并提出实验预测来验证它。
