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本文引用的文献

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Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites.具有环状拓扑结构的木瓜样 NlpC/P60 超家族酶的结构分析揭示了潜在的脂质结合位点。
PLoS One. 2011;6(7):e22013. doi: 10.1371/journal.pone.0022013. Epub 2011 Jul 22.
2
Peptidoglycan turnover and recycling in Gram-positive bacteria.革兰氏阳性菌中肽聚糖的周转和再循环。
Appl Microbiol Biotechnol. 2011 Oct;92(1):1-11. doi: 10.1007/s00253-011-3486-x. Epub 2011 Jul 28.
3
A novel transglutaminase substrate from Streptomyces mobaraensis inhibiting papain-like cysteine proteases.一株来源于藤黄微球菌的新型转谷氨酰胺酶底物抑制木瓜样半胱氨酸蛋白酶。
J Microbiol Biotechnol. 2011 Jun;21(6):617-26.
4
How pathogen-derived cysteine proteases modulate host immune responses.病原体来源的半胱氨酸蛋白酶如何调节宿主免疫反应。
Adv Exp Med Biol. 2011;712:192-207. doi: 10.1007/978-1-4419-8414-2_12.
5
The lysine-specific gingipain of Porphyromonas gingivalis : importance to pathogenicity and potential strategies for inhibition.牙龈卟啉单胞菌的赖氨酸特异性gingipain：对致病性的重要性及潜在的抑制策略。
Adv Exp Med Biol. 2011;712:15-29. doi: 10.1007/978-1-4419-8414-2_2.
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Papain-like proteases of Staphylococcus aureus.金黄色葡萄球菌的木瓜蛋白酶样蛋白酶。
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Peptide-based fluorescence resonance energy transfer protease substrates for the detection and diagnosis of Bacillus species.基于肽的荧光共振能量转移蛋白酶底物用于检测和诊断芽孢杆菌属。
Anal Chem. 2011 Apr 1;83(7):2511-7. doi: 10.1021/ac102764v. Epub 2011 Mar 3.
8
Yersinia enterocolitica outer protein T (YopT).耶尔森氏菌外蛋白 T（YopT）。
Eur J Cell Biol. 2011 Nov;90(11):955-8. doi: 10.1016/j.ejcb.2010.12.005. Epub 2011 Jan 20.
9
Virulence mechanisms of Tannerella forsythia.具核梭杆菌的致病机制。
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10
Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders.木瓜蛋白酶样半胱氨酸蛋白酶：植物及其入侵者在分子战场上的关键参与者。
Mol Plant Pathol. 2008 Jan;9(1):119-25. doi: 10.1111/j.1364-3703.2007.00439.x.

藤黄微球菌蛋白酶抑制剂（SPI）能够抑制细菌半胱氨酸蛋白酶，是细菌生长的拮抗剂。

The papain inhibitor (SPI) of Streptomyces mobaraensis inhibits bacterial cysteine proteases and is an antagonist of bacterial growth.

机构信息

Department of Chemical Engineering and Biotechnology, University of Applied Sciences of Darmstadt, Darmstadt, Germany.

出版信息

Antimicrob Agents Chemother. 2013 Jul;57(7):3388-91. doi: 10.1128/AAC.00129-13. Epub 2013 Apr 15.

DOI:10.1128/AAC.00129-13
PMID:23587952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3697372/
Abstract

A novel papain inhibitory protein (SPI) from Streptomyces mobaraensis was studied to measure its inhibitory effect on bacterial cysteine protease activity (Staphylococcus aureus SspB) and culture supernatants (Porphyromonas gingivalis, Bacillus anthracis). Further, growth of Bacillus anthracis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio cholerae was completely inhibited by 10 μM SPI. At this concentration of SPI, no cytotoxicity was observed. We conclude that SPI inhibits bacterial virulence factors and has the potential to become a novel therapeutic treatment against a range of unrelated pathogenic bacteria.

摘要

一种新型木瓜蛋白酶抑制蛋白（SPI）来自藤黄微球菌，研究其对细菌半胱氨酸蛋白酶活性（金黄色葡萄球菌 SspB）和培养上清液（牙龈卟啉单胞菌、炭疽芽孢杆菌）的抑制作用。此外，10μM SPI 完全抑制炭疽芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和霍乱弧菌的生长。在 SPI 的这个浓度下，没有观察到细胞毒性。我们得出结论，SPI 抑制细菌毒力因子，并有潜力成为一种针对一系列无关致病菌的新型治疗方法。