Kaman W E, Hays J P, Endtz H P, Bikker F J
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands,
Eur J Clin Microbiol Infect Dis. 2014 Jul;33(7):1081-7. doi: 10.1007/s10096-014-2075-1. Epub 2014 Feb 18.
Proteases are essential for the proliferation and growth of bacteria, and are also known to contribute to bacterial virulence. This makes them interesting candidates as diagnostic and therapeutic targets for infectious diseases. In this review, the authors discuss the most recent developments and potential applications for bacterial proteases in the diagnosis and treatment of bacterial infections. Current and future bacterial protease targets are described and their limitations outlined.
蛋白酶对于细菌的增殖和生长至关重要，并且已知其有助于细菌的毒力。这使得它们成为传染病诊断和治疗靶点的有趣候选对象。在本综述中，作者讨论了细菌蛋白酶在细菌感染诊断和治疗方面的最新进展及潜在应用。描述了当前和未来的细菌蛋白酶靶点，并概述了它们的局限性。
