Dobbin Zachary C, Landen Charles N
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35233, USA.
Int J Mol Sci. 2013 Apr 15;14(4):8213-27. doi: 10.3390/ijms14048213.
Ovarian cancer is the fifth most common cause of death due to cancer in women despite being the tenth in incidence. Unfortunately, the five-year survival rate is only 45%, which has not improved much in the past 30 years. Even though the majority of women have successful initial therapy, the low rate of survival is due to the eventual recurrence and succumbing to their disease. With the recent release of the Cancer Genome Atlas for ovarian cancer, it was shown that the PI3K/AKT/mTOR pathway was one of the most frequently mutated or altered pathways in patients' tumors. Researching how the PI3K/AKT/mTOR pathway affects the progression and tumorigensis of ovarian cancer will hopefully lead to new therapies that will increase survival for women. This review focuses on recent research on the PI3K/AKT/mTOR pathway and its role in the progression and tumorigensis of ovarian cancer.
卵巢癌是女性因癌症死亡的第五大常见原因,尽管其发病率仅排在第十位。不幸的是,其五年生存率仅为45%,在过去30年里并没有太大改善。尽管大多数女性初始治疗成功,但生存率低是由于最终复发并死于该疾病。随着最近卵巢癌癌症基因组图谱的发布,研究表明PI3K/AKT/mTOR通路是患者肿瘤中最常发生突变或改变的通路之一。研究PI3K/AKT/mTOR通路如何影响卵巢癌的进展和肿瘤发生有望带来新的疗法,从而提高女性的生存率。本综述重点关注PI3K/AKT/mTOR通路的最新研究及其在卵巢癌进展和肿瘤发生中的作用。