Department of Computational Biology and Bioinformatics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
PLoS One. 2013 Apr 12;8(4):e61047. doi: 10.1371/journal.pone.0061047. Print 2013.
Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between hsa-miR-196a2 rs11614913 polymorphism and increased/decreased lung cancer risk. In the present study, we performed a meta-analysis to systematically summarize the possible association.
METHODOLOGY/PRINCIPAL FINDINGS: We performed a meta-analysis of 4 case-control studies that included 2219 lung-cancer cases and 2232 cancer-free controls. We evaluated the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In the overall analysis, it was found that the rs11614913 polymorphism significantly elevated the risk of lung cancer (CC versus (vs.) TT OR = 1.26, 95% CI 1.07-1.49, P = 0.007; CC/CT vs. TT: OR = 1.13, 95% CI 0.98-1.29, P = 0.007; C vs. T: OR = 1.12, 95% CI 1.03-1.22, P = 0.008). In the subgroup analysis by ethnicity, statistically significantly increased cancer risk was found among Asians (CC vs. TT: OR = 1.30, 95% CI 1.10-1.54, P = 0.003; CT vs. TT: OR = 1.16, 95% CI 1.01-1.34, P = 0.039; CC vs. CT/TT: OR = 1.21, 95% CI 1.04-1.41, P = 0.012; C vs. T: OR = 1.14, 95% CI 1.05-1.25, P = 0.002). For Europeans, a significant association with lung cancer risk was found in recessive model (CC vs. CT/TT: OR = 0.63, 95% CI 0.40-0.98, P = 0.040). No publication bias was found in this study.
CONCLUSIONS/SIGNIFICANCE: Our meta-analysis suggests that the rs11614913 polymorphism is significant associated with the increased risk of lung cancer, especially in Asians. Besides, the C allele of rs11614913 polymorphism may contribute to increased lung cancer risk.
新兴证据表明，微小 RNA 编码基因中的单核苷酸多态性（SNPs）可能通过改变与肿瘤相关的微小 RNA 的表达参与肺癌的发病机制。近年来，有几项研究评估了 hsa-miR-196a2 rs11614913 多态性与肺癌风险增加/降低之间的关系。在本研究中，我们进行了荟萃分析以系统地总结可能的关联。
方法/主要发现：我们对包括 2219 例肺癌病例和 2232 例无癌症对照的 4 项病例对照研究进行了荟萃分析。我们使用 95%置信区间（CI）的优势比（ORs）来评估关联的强度。在总体分析中，发现 rs11614913 多态性显著增加了肺癌的风险（CC 与 TT 相比 OR=1.26，95%CI 1.07-1.49，P=0.007；CC/CT 与 TT 相比 OR=1.13，95%CI 0.98-1.29，P=0.007；C 与 T 相比 OR=1.12，95%CI 1.03-1.22，P=0.008）。按种族进行亚组分析时，发现亚洲人群的癌症风险显著增加（CC 与 TT 相比 OR=1.30，95%CI 1.10-1.54，P=0.003；CT 与 TT 相比 OR=1.16，95%CI 1.01-1.34，P=0.039；CC 与 CT/TT 相比 OR=1.21，95%CI 1.04-1.41，P=0.012；C 与 T 相比 OR=1.14，95%CI 1.05-1.25，P=0.002）。对于欧洲人，在隐性模型中发现与肺癌风险有显著关联（CC 与 CT/TT 相比 OR=0.63，95%CI 0.40-0.98，P=0.040）。本研究未发现发表偏倚。
结论/意义：我们的荟萃分析表明，rs11614913 多态性与肺癌风险增加显著相关，尤其是在亚洲人群中。此外，rs11614913 多态性的 C 等位基因可能导致肺癌风险增加。
