Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center, Department of Molecular & Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
PLoS One. 2011 Mar 31;6(3):e18108. doi: 10.1371/journal.pone.0018108.
MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, Pheterogeneity=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, Pheterogeneity=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, Pheterogeneity=0.006).
These findings supported that hsa-miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of cancers.
microRNAs (miRNAs) 是一类内源性、小的、非编码 RNA，通过抑制翻译或降解 mRNA 来负调控基因表达。最近，许多研究调查了 hsa-miR-196a2 rs11614913 多态性与癌症风险之间的关联，但其结果并不一致。
方法/主要发现： 我们对包括 9341 例癌症病例和 10569 例无癌症对照的 15 项研究进行了荟萃分析。我们使用比值比 (OR) 和 95%置信区间 (CI) 来评估关联的强度。总体而言，TC/CC 基因型个体与癌症风险增加相关，与 TT 基因型相比，OR=1.18 (95% CI=1.03-1.34，P<0.001，异质性检验)。在分层分析中，我们观察到 CC 基因型可能调节乳腺癌风险 (OR=1.11，95%CI=1.01-1.23，P 异质性=0.210) 和肺癌风险 (OR=1.25，95%CI=1.06-1.46，P 异质性=0.958)，与 TC/TT 基因型相比。此外，在显性模型中，亚洲人群中发现了显著增加的风险 (TC/CC 与 TT 相比，OR=1.24，95% CI=1.07-1.43，P 异质性=0.006)。
这些发现支持 hsa-miR-196a2 rs11614913 多态性可能导致癌症易感性。
