Warwick Medical School, University of Warwick, Coventry, UK.
J Hum Hypertens. 2013 Oct;27(10):583-8. doi: 10.1038/jhh.2013.27. Epub 2013 Apr 18.
The global increase in both coronary heart disease (CHD) and cardiovascular disease (CVD) and the associated increase in undetected subclinical cardiovascular pathology highlight the continuing need for improved risk prediction. Traditional risk factors fail to identify all 'at-risk' individuals. Although new risk factors, associated with endothelial function, inflammatory and oxidative stress pathways, for example, have been identified, studies have often observed only minimal improved risk classification when such markers are added. We examine the emerging evidence that short sleep may be a risk factor for obesity, type 2 diabetes and hypertension, and an independent predictor of stroke, CHD and CVD. We examine the underlying mechanisms and the evidence to suggest that short sleep may modulate the association between established factors and CVD. We consider whether the levels of markers of obesity and appetite control, energy metabolism, glucose homoeostasis, inflammation, thrombosis and haemostasis, which are affected by short duration of sleep, might be useful predictors of the risk of developing CVD. Finally, the usefulness of such markers for disease detection, management and prevention is considered.
全球范围内冠心病 (CHD) 和心血管疾病 (CVD) 的增加，以及与之相关的未被发现的亚临床心血管病理的增加，突出表明需要改进风险预测。传统的风险因素无法识别所有“高危”个体。尽管已经确定了与内皮功能、炎症和氧化应激途径相关的新的风险因素，但当添加这些标志物时，研究通常只观察到风险分类的微小改善。我们研究了睡眠不足可能是肥胖、2 型糖尿病和高血压的风险因素，以及中风、CHD 和 CVD 的独立预测因素的新证据。我们研究了潜在的机制，并提出证据表明，短睡眠可能会调节已确定的因素与 CVD 之间的关联。我们考虑了受短睡眠时间影响的肥胖和食欲控制、能量代谢、血糖稳态、炎症、血栓形成和止血标志物的水平，是否可以作为发生 CVD 风险的有用预测指标。最后，还考虑了这些标志物在疾病检测、管理和预防方面的用途。
