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高剂量达托霉素单药治疗在传统治疗失败后可治愈表皮葡萄球菌“内置导管相关感染”。

High-dose daptomycin monotherapy cures Staphylococcus epidermidis 'endotipsitis' after failure of conventional therapy.

作者信息

Colston Julia Marie, Scarborough Matthew, Collier Jane, Bowler Ian C J W

机构信息

Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, Oxford, UK.

出版信息

BMJ Case Rep. 2013 Apr 16;2013:bcr2013009529. doi: 10.1136/bcr-2013-009529.

DOI:10.1136/bcr-2013-009529
PMID:23595199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3645644/
Abstract

A 67-year-old gentleman developed persistent Staphylococcus epidermidis bacteraemia following transjugular intrahepatic portal shunting. 'Endotipsitis' was diagnosed. Conventional therapy with a vancomycin infusion, amikacin and rifampicin failed after 17 days. He was cured with a 6-week course of high-dose (8 mg/kg) daptomycin monotherapy.

摘要

一名67岁男性在经颈静脉肝内门体分流术后发生持续性表皮葡萄球菌菌血症，诊断为“内置分流管炎”。使用万古霉素静脉输注、阿米卡星和利福平进行的常规治疗在17天后失败。他接受了为期6周的高剂量（8mg/kg）达托霉素单药治疗并痊愈。

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Antimicrob Agents Chemother. 2012 Dec;56(12):6192-200. doi: 10.1128/AAC.01525-12. Epub 2012 Sep 17.
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Successful treatment of a left ventricular assist device infection with daptomycin non-susceptible methicillin-resistant Staphylococcus aureus: case report and review of the literature.用对达托霉素不敏感的耐甲氧西林金黄色葡萄球菌成功治疗左心室辅助装置感染：病例报告及文献综述
Transpl Infect Dis. 2012 Oct;14(5):E89-96. doi: 10.1111/j.1399-3062.2012.00775.x. Epub 2012 Aug 30.
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