双[锌（II）二吡啶氨基]-功能化肽作为水中焦磷酸离子的高亲和受体。
Bis[zinc(II)dipicolylamino]-functionalised peptides as high affinity receptors for pyrophosphate ions in water.
机构信息
School of Chemistry, The University of Sydney, 2006, NSW, Australia.
出版信息
Chem Commun (Camb). 2013 May 25;49(42):4824-6. doi: 10.1039/c3cc40937f.
A library of bis[zinc(II)dipicolylamine]-functionalised linear peptides was prepared using an efficient solid phase peptide synthesis approach and their use as chemosensors for anions in water was investigated using indicator displacement assays. High affinity and selectivity for pyrophosphate (PPi) over adenosine triphosphate (ATP) and adenosine diphosphate (ADP) were observed and additional aromatic side chains provided enhanced discrimination between PPi and ATP.
使用高效的固相肽合成方法制备了一系列双[锌（II）二吡啶胺]功能化线性肽库，并使用指示剂置换测定法研究了它们在水中作为阴离子化学传感器的用途。观察到焦磷酸盐（PPi）对三磷酸腺苷（ATP）和二磷酸腺苷（ADP）具有高亲和力和选择性，并且额外的芳香侧链提供了对 PPi 和 ATP 之间的增强区分。
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