McLean Hospital Belmont, MA, USA ; Department of Psychiatry, Harvard Medical School Boston, MA, USA.
Front Integr Neurosci. 2013 Apr 11;7:24. doi: 10.3389/fnint.2013.00024. eCollection 2013.
In this manuscript we present novel MRI approaches to dissecting axon vs. myelin abnormalities in psychiatric disorders. Existing DTI approaches are not able to provide specific information on these subcellular elements but novel approaches are beginning to do so. We review two approaches (magnetization transfer ratio-MTR; and diffusion tensor spectroscopy-DTS) and the theoretical framework for interpreting data derived from these approaches. Work is ongoing to collect data that will answer some relevant questions using these techniques in schizophrenia and related conditions.
在本手稿中，我们提出了新的 MRI 方法来剖析精神疾病中的轴突与髓鞘异常。现有的 DTI 方法无法提供这些亚细胞成分的具体信息，但新的方法开始能够做到这一点。我们回顾了两种方法（磁化传递率-MTR；和扩散张量光谱-DTS）以及解释这些方法得出的数据的理论框架。目前正在收集数据，以便使用这些技术在精神分裂症和相关疾病中回答一些相关问题。
